单核细胞增生李斯特菌的应答调节因子DegU在其未磷酸化状态下控制温度响应性鞭毛基因表达。
Response regulator DegU of Listeria monocytogenes controls temperature-responsive flagellar gene expression in its unphosphorylated state.
作者信息
Mauder Norman, Williams Tatjana, Fritsch Frederike, Kuhn Michael, Beier Dagmar
机构信息
Theodor-Boveri-Institut für Biowissenschaften, Lehrstuhl für Mikrobiologie, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany.
出版信息
J Bacteriol. 2008 Jul;190(13):4777-81. doi: 10.1128/JB.00258-08. Epub 2008 Apr 25.
Abstract
We demonstrate that in Listeria monocytogenes, temperature-responsive transcriptional control of flagellar genes does not rely on the phosphorylation of the conserved phosphorylation site (D55) in the receiver domain of response regulator DegU. Furthermore, proper control of DegU-regulated genes involved in ethanol tolerance and virulence is independent of receiver phosphorylation.
摘要
我们证明，在单核细胞增生李斯特菌中，鞭毛基因的温度响应转录调控并不依赖于响应调节因子DegU的接收结构域中保守磷酸化位点（D55）的磷酸化。此外，对参与乙醇耐受性和毒力的DegU调控基因的适当控制与接收结构域磷酸化无关。
相似文献
1
Response regulator DegU of Listeria monocytogenes controls temperature-responsive flagellar gene expression in its unphosphorylated state.
J Bacteriol. 2008 Jul;190(13):4777-81. doi: 10.1128/JB.00258-08. Epub 2008 Apr 25.
2
Transcriptional and post-transcriptional regulation of the GmaR antirepressor governs temperature-dependent control of flagellar motility in Listeria monocytogenes.
Mol Microbiol. 2009 Oct;74(2):421-35. doi: 10.1111/j.1365-2958.2009.06874.x. Epub 2009 Oct 1.
3
The Pta-AckA pathway controlling acetyl phosphate levels and the phosphorylation state of the DegU orphan response regulator both play a role in regulating Listeria monocytogenes motility and chemotaxis.
Mol Microbiol. 2008 Dec;70(6):1342-57. doi: 10.1111/j.1365-2958.2008.06496.x. Epub 2008 Oct 17.
4
Structural and biochemical analyses of the flagellar expression regulator DegU from Listeria monocytogenes.
Sci Rep. 2022 Jul 7;12(1):10856. doi: 10.1038/s41598-022-14459-5.
5
The DegU orphan response regulator of Listeria monocytogenes autorepresses its own synthesis and is required for bacterial motility, virulence and biofilm formation.
Microbiology (Reading). 2008 Aug;154(Pt 8):2251-2264. doi: 10.1099/mic.0.2008/017590-0.
6
Characterization of DegU, a response regulator in Listeria monocytogenes, involved in regulation of motility and contributes to virulence.
FEMS Microbiol Lett. 2004 Nov 15;240(2):171-9. doi: 10.1016/j.femsle.2004.09.039.
7
Response regulator DegU of Listeria monocytogenes regulates the expression of flagella-specific genes.
FEMS Microbiol Lett. 2005 Nov 15;252(2):287-98. doi: 10.1016/j.femsle.2005.09.011. Epub 2005 Sep 22.
8
Listeria monocytogenes regulates flagellar motility gene expression through MogR, a transcriptional repressor required for virulence.
Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12318-23. doi: 10.1073/pnas.0404924101. Epub 2004 Aug 9.
9
Listeria monocytogenes DNA Glycosylase AdlP Affects Flagellar Motility, Biofilm Formation, Virulence, and Stress Responses.
Appl Environ Microbiol. 2016 Aug 15;82(17):5144-52. doi: 10.1128/AEM.00719-16. Print 2016 Sep 1.
10
The MogR transcriptional repressor regulates nonhierarchal expression of flagellar motility genes and virulence in Listeria monocytogenes.
PLoS Pathog. 2006 Apr;2(4):e30. doi: 10.1371/journal.ppat.0020030. Epub 2006 Apr 14.
引用本文的文献
1
DegU-mediated suppression of carbohydrate uptake in increases adaptation to oxidative stress.
Appl Environ Microbiol. 2023 Oct 31;89(10):e0101723. doi: 10.1128/aem.01017-23. Epub 2023 Oct 3.
2
Structural and biochemical analyses of the flagellar expression regulator DegU from Listeria monocytogenes.
Sci Rep. 2022 Jul 7;12(1):10856. doi: 10.1038/s41598-022-14459-5.
3
The DegU Orphan Response Regulator Contributes to Heat Stress Resistance in .
Front Cell Infect Microbiol. 2021 Dec 13;11:761335. doi: 10.3389/fcimb.2021.761335. eCollection 2021.
4
Application of Whole Genome Sequencing to Aid in Deciphering the Persistence Potential of in Food Production Environments.
Microorganisms. 2021 Aug 31;9(9):1856. doi: 10.3390/microorganisms9091856.
5
Ascorbic Acid Changes Growth of Food-Borne Pathogens in the Early Stage of Biofilm Formation.
Microorganisms. 2020 Apr 11;8(4):553. doi: 10.3390/microorganisms8040553.
6
Listeria monocytogenes DNA Glycosylase AdlP Affects Flagellar Motility, Biofilm Formation, Virulence, and Stress Responses.
Appl Environ Microbiol. 2016 Aug 15;82(17):5144-52. doi: 10.1128/AEM.00719-16. Print 2016 Sep 1.
7
Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes.
J Bacteriol. 2014 Nov;196(21):3756-67. doi: 10.1128/JB.02053-14. Epub 2014 Aug 25.
8
The CLO3403/CLO3404 two-component system of Clostridium botulinum E1 Beluga is important for cold shock response and growth at low temperatures.
Appl Environ Microbiol. 2014 Jan;80(1):399-407. doi: 10.1128/AEM.03204-13. Epub 2013 Nov 1.
9
A novel restriction-modification system is responsible for temperature-dependent phage resistance in Listeria monocytogenes ECII.
Appl Environ Microbiol. 2012 Mar;78(6):1995-2004. doi: 10.1128/AEM.07086-11. Epub 2012 Jan 13.
10
Illuminating the landscape of host-pathogen interactions with the bacterium Listeria monocytogenes.
Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19484-91. doi: 10.1073/pnas.1112371108. Epub 2011 Nov 23.
本文引用的文献
1
A bifunctional O-GlcNAc transferase governs flagellar motility through anti-repression.
Genes Dev. 2006 Dec 1;20(23):3283-95. doi: 10.1101/gad.1492606.
2
Interference of components of the phosphoenolpyruvate phosphotransferase system with the central virulence gene regulator PrfA of Listeria monocytogenes.
J Bacteriol. 2007 Jan;189(2):473-90. doi: 10.1128/JB.00972-06. Epub 2006 Nov 3.
3
Characterization of the ArsRS regulon of Helicobacter pylori, involved in acid adaptation.
J Bacteriol. 2006 May;188(10):3449-62. doi: 10.1128/JB.188.10.3449-3462.2006.
4
The MogR transcriptional repressor regulates nonhierarchal expression of flagellar motility genes and virulence in Listeria monocytogenes.
PLoS Pathog. 2006 Apr;2(4):e30. doi: 10.1371/journal.ppat.0020030. Epub 2006 Apr 14.
5
Response regulator DegU of Listeria monocytogenes regulates the expression of flagella-specific genes.
FEMS Microbiol Lett. 2005 Nov 15;252(2):287-98. doi: 10.1016/j.femsle.2005.09.011. Epub 2005 Sep 22.
6
Construction and characterization of Listeria monocytogenes mutants with in-frame deletions in the response regulator genes identified in the genome sequence.
Infect Immun. 2005 May;73(5):3152-9. doi: 10.1128/IAI.73.5.3152-3159.2005.
7
Characterization of DegU, a response regulator in Listeria monocytogenes, involved in regulation of motility and contributes to virulence.
FEMS Microbiol Lett. 2004 Nov 15;240(2):171-9. doi: 10.1016/j.femsle.2004.09.039.
8
Listeria monocytogenes regulates flagellar motility gene expression through MogR, a transcriptional repressor required for virulence.
Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12318-23. doi: 10.1073/pnas.0404924101. Epub 2004 Aug 9.
9
Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity.
Cell Microbiol. 2004 Mar;6(3):235-42. doi: 10.1046/j.1462-5822.2004.00360.x.
10
Comparative genomics of Listeria species.
Science. 2001 Oct 26;294(5543):849-52. doi: 10.1126/science.1063447.
Zotero 插件