Unité des Interactions Bactéries-Cellules, Département de Biologie Cellulaire et Infection, Institut Pasteur, F-75015 Paris, France.
Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19484-91. doi: 10.1073/pnas.1112371108. Epub 2011 Nov 23.
Listeria monocytogenes has, in 25 y, become a model in infection biology. Through the analysis of both its saprophytic life and infectious process, new concepts in microbiology, cell biology, and pathogenesis have been discovered. This review will update our knowledge on this intracellular pathogen and highlight the most recent breakthroughs. Promising areas of investigation such as the increasingly recognized relevance for the infectious process, of RNA-mediated regulations in the bacterium, and the role of bacterially controlled posttranslational and epigenetic modifications in the host will also be discussed.
短短 25 年间，李斯特菌已成为感染生物学领域的研究典范。通过分析其腐生生活和感染过程，人们发现了微生物学、细胞生物学和发病机制领域的新概念。本综述将更新我们对这种细胞内病原体的认识，并重点介绍最新的研究突破。还将讨论一些有前景的研究领域，如细菌内部 RNA 调控在感染过程中的重要性，以及细菌控制的宿主翻译后修饰和表观遗传修饰的作用。
