Albanidou-Farmaki Eleni, Poulopoulos Athanasios K, Epivatianos Apostolos, Farmakis Konstantinos, Karamouzis Michalis, Antoniades Demetrios
Department of Oral Medicine and Pathology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Tohoku J Exp Med. 2008 Apr;214(4):291-6. doi: 10.1620/tjem.214.291.
Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal disorders. The aim of the study was to determine any association between anxiety levels and concentrations of salivary and serum cortisol in patients with RAS. It has been suggested that stress with its presumed effects on the immune system, constitutes one of the major causative agents of RAS. The concentrations of salivary and serum cortisol were measured in 38 patients with recurrent aphthous stomatitis, and 38 healthy controls. Salivary and serum cortisol levels were measured using a Luminenscent Immunoassay (LIA) method. Anxiety levels were evaluated using Spielberger's State-Trait Anxiety Inventory which measures both trait anxiety as a general aspect of personality (STAI-T) and state anxiety as a response to a specific situation (STAI-S). The salivary cortisol levels were 1.44 (+/- 0.58) microg dl(-1) in RAS patients and 0.91 (+/- 0.56) microg dl(-1) in controls (p = 0.001), while the serum cortisol levels were 3.13 (+/- 1.59) microg dl(-1) in RAS patients and 1.89 (+/- 1.11) microg dl(-1) in controls (p = 0.001). The state anxiety levels (STAI-S) were 48.85 (+/- 9.7) in RAS group and 39.45 (+/- 7.5) in control group (p = 0.001). The trait anxiety levels (STAI-T) were 49.78 (+/- 13.02) in RAS group and 38.49 (+/- 10.31) in control group (p = 0.001). Salivary and serum cortisol concentrations and state and trait anxiety levels in RAS were significantly higher than those in the control group. Our results suggest that stress may be involved in the pathogenesis of RAS.
复发性阿弗他口炎（RAS）是最常见的口腔黏膜疾病之一。本研究的目的是确定RAS患者的焦虑水平与唾液及血清皮质醇浓度之间是否存在关联。有人认为，压力及其对免疫系统的假定影响是RAS的主要致病因素之一。对38例复发性阿弗他口炎患者和38名健康对照者测量了唾液和血清皮质醇浓度。采用发光免疫分析（LIA）法测量唾液和血清皮质醇水平。使用斯皮尔伯格状态-特质焦虑量表评估焦虑水平，该量表测量作为人格一般方面的特质焦虑（STAI-T）和作为对特定情况反应的状态焦虑（STAI-S）。RAS患者的唾液皮质醇水平为1.44（±0.58）μg dl⁻¹，对照组为0.91（±0.56）μg dl⁻¹（p = 0.001），而RAS患者的血清皮质醇水平为3.13（±1.59）μg dl⁻¹，对照组为1.89（±1.11）μg dl⁻¹（p = 0.001）。RAS组的状态焦虑水平（STAI-S）为48.85（±9.7），对照组为39.45（±7.5）（p = 0.001）。RAS组的特质焦虑水平（STAI-T）为49.78（±13.02），对照组为38.49（±10.31）（p = 0.001）。RAS患者的唾液和血清皮质醇浓度以及状态和特质焦虑水平显著高于对照组。我们的结果表明，压力可能参与了RAS的发病机制。
