Kunikullaya U. Kirthana, Kumar M. Arun, Ananthakrishnan Vasanthi, Jaisri Goturu
Department of Physiology, M S Ramaiah Medical College and Hospitals, MSR Nagar, MSRIT Post, Bangalore, Karnataka 560054, India.
Department of Physiology, International Medical School, MSR Nagar, MSRIT Post, Bangalore, Karanataka 560054, India.
Chin J Physiol. 2017 Aug 31;60(4):226-230. doi: 10.4077/CJP.2017.BAF462.
Stress causes an increase in cortisol and amylase. Recurrent aphthous stomatitis (RAS) results due to a multitude of causes, amongst which stress is one of the most important. Aim of the study was to estimate the level of stress, serum cortisol, salivary cortisol, amylase and electrolytes in subjects with RAS. 34 subjects with RAS (cases) were compared with 34 controls. Stress was measured using state trait anxiety inventory (STAI). Serum cortisol (Radioimmunoassay), Salivary cortisol, amylase (ELISA) and electrolytes (Flame photometry) were measured. Statistical analysis was done using SPSS 18.0 version software. The mean STAI scores were 48.71 ± 4.6 in cases and 46.74 ± 6.4 in controls (P = 0.13). The mean salivary cortisol concentration was 3.35 ± 1.8 ng/dl in cases and 3.65 ± 2.5 ng/dl in controls (P = 0.78). The mean salivary amylase was 155.09 ± 116.1 U/ml in cases and 128.74 ± 86.3 U/ml in controls (P = 0.49). The salivary sodium (0.24 ± 0.4 in both groups) and potassium (0.65 ± 0.5 in cases and 0.82 ± 0.4 in controls; P = 0.07) was not different in the two groups (electrolytes in mEq/dl). No correlation was seen between the salivary stress markers and STAI scores. Though stress was higher in RAS group none of the measured parameters were different from the control group. Stress may cause RAS but, in this study, there was no change in the salivary homeostasis.
压力会导致皮质醇和淀粉酶水平升高。复发性阿弗他口炎（RAS）由多种原因引起，其中压力是最重要的原因之一。本研究的目的是评估RAS患者的压力水平、血清皮质醇、唾液皮质醇、淀粉酶和电解质。将34例RAS患者（病例组）与34例对照组进行比较。使用状态特质焦虑量表（STAI）测量压力。测量血清皮质醇（放射免疫分析）、唾液皮质醇、淀粉酶（酶联免疫吸附测定）和电解质（火焰光度法）。使用SPSS 18.0版软件进行统计分析。病例组的平均STAI评分为48.71±4.6，对照组为46.74±6.4（P = 0.13）。病例组的平均唾液皮质醇浓度为3.35±1.8 ng/dl，对照组为3.65±2.5 ng/dl（P = 0.78）。病例组的平均唾液淀粉酶为155.09±116.1 U/ml，对照组为128.74±86.3 U/ml（P = 0.49）。两组的唾液钠（两组均为0.24±0.4）和钾（病例组为0.65±0.5，对照组为0.82±0.4；P = 0.07）无差异（电解质单位为mEq/dl）。唾液应激标志物与STAI评分之间无相关性。虽然RAS组的压力较高，但所测量的参数与对照组均无差异。压力可能导致RAS，但在本研究中，唾液内环境稳态没有变化。
