McCartan B E, Lamey P J, Wallace A M
Department of Oral Surgery, Oral Medicine and Oral Pathology, School of Dental Science, Trinity College, Dublin, Ireland.
J Oral Pathol Med. 1996 Aug;25(7):357-9. doi: 10.1111/j.1600-0714.1996.tb00278.x.
Anxiety and salivary cortisol were measured in two groups of patients with recurrent aphthous ulceration. One group of patients had persistent aphthae (Group 1) and the others had been relieved of their aphthae following correction of detected haematinic deficiency states (Group 2). Anxiety was measured using the Hospital Anxiety and Depression scale and radioimmunoassay of salivary cortisol. There was a statistically significant increased proportion of borderline or clinically anxious patients in Group 1 compared to Group 2 (P < 0.05). Median salivary cortisol levels also showed a statistically significant elevation in Group 1 (P < 0.01). It is concluded that stress may play a role in the aetiology of recurrent aphthous stomatitis, particularly in patients who have an underlying anxiety trait.
对两组复发性阿弗他溃疡患者进行了焦虑和唾液皮质醇水平的测量。一组患者患有持续性口疮（第1组），另一组患者在纠正检测到的造血物质缺乏状态后口疮得到缓解（第2组）。使用医院焦虑和抑郁量表以及唾液皮质醇放射免疫测定法来测量焦虑程度。与第2组相比，第1组中处于临界或临床焦虑状态的患者比例在统计学上有显著增加（P < 0.05）。第1组的唾液皮质醇水平中位数也显示出统计学上的显著升高（P < 0.01）。得出的结论是，压力可能在复发性阿弗他口炎的病因中起作用，尤其是在具有潜在焦虑特质的患者中。
