Büyükgebiz A, Ciliv G, Kinik E
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Turk J Pediatr. 1991 Jan-Mar;33(1):19-25.
The study population consisted of 144 healthy, non-obese male adolescents, aged between 11-18 years, who were in different stages of sexual maturation as described by Tanner. The fasting plasma cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (C-HDL), low density lipoprotein cholesterol (C-LDL), and very low density lipoprotein cholesterol (C-VLDL) levels were calculated for each subject. There were significant differences observed in the following: mean TC levels between G1 and G2; mean C-HDL levels between G2 and G3 and between G3 and G4; mean TG levels between G1 and G2 and between G2 and G3; mean C-LDL levels between G1 and G2, and mean C-VLDL levels between G1 and G2 and between G2 and G3. There were no significant differences for lipids and lipoproteins between the prepubertal (G1) and postpubertal (G5) stages. It is generally believed that testosterone may play a role in mediating lipid and lipoprotein levels in the pubertal phase, but, since we found no significant differences in the levels of lipids and lipoproteins between G1 and G5, and also because these levels fluctuated from G1 to G5, it strongly suggests that the effect of testosterone on lipids and lipoproteins is dependent on other factors such as hormones, dietary habits, age, race, etc.
研究对象包括144名健康、非肥胖的男性青少年，年龄在11至18岁之间，处于坦纳所描述的不同性成熟阶段。计算了每名受试者的空腹血浆胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（C-HDL）、低密度脂蛋白胆固醇（C-LDL）和极低密度脂蛋白胆固醇（C-VLDL）水平。在以下方面观察到显著差异：G1和G2之间的平均TC水平；G2和G3之间以及G3和G4之间的平均C-HDL水平；G1和G2之间以及G2和G3之间的平均TG水平；G1和G2之间的平均C-LDL水平，以及G1和G2之间以及G2和G3之间的平均C-VLDL水平。青春期前（G1）和青春期后（G5）阶段之间的脂质和脂蛋白水平没有显著差异。一般认为，睾酮可能在青春期介导脂质和脂蛋白水平方面发挥作用，但是，由于我们发现G1和G5之间的脂质和脂蛋白水平没有显著差异，而且这些水平从G1到G5有波动，这强烈表明睾酮对脂质和脂蛋白的影响取决于其他因素，如激素、饮食习惯、年龄、种族等。
