Poulsen Steen Hvitfeldt, Praestholm Michael, Munk Kim, Wierup Per, Egeblad Henrik, Nielsen-Kudsk Jens Erik
Department of Cardiology, Aarhus University Hospital, Skejby, Denmark.
Ann Thorac Surg. 2008 May;85(5):1591-6. doi: 10.1016/j.athoracsur.2008.01.010.
The objective of this paper was to study the patient characteristics and contemporary short- and long-term outcome in patients with postinfarct ventricular septal rupture.
Based on patient files and register data we performed a review of 64 consecutive patients with ventricular septal rupture complicating acute myocardial infarction, admitted to our tertiary center.
The mean age of the patients was 70 +/- 7. The median time was five days from onset of symptoms to the diagnosis of the ventricular septal rupture. The overall 30-day, one-, and five- year mortalities were 62%, 72%, and 95%, respectively. Medical treated patients (n = 19) had a 30-day mortality of 100%. Among surgically treated patients (n = 45) the survival at one month, one and five years was 71%, 48%, and 32%, respectively. History of hypertension, complicating congestive heart failure, and age were associated with poor outcome.
Despite improvements in medical and interventional techniques the early as well as the long-term prognosis remains poor in this contemporary series.
本文旨在研究心肌梗死后室间隔破裂患者的特征以及当代的短期和长期预后情况。
基于患者病历和登记数据，我们对连续64例因急性心肌梗死并发室间隔破裂而入住我们三级中心的患者进行了回顾性研究。
患者的平均年龄为70±7岁。从症状出现到室间隔破裂诊断的中位时间为5天。30天、1年和5年的总体死亡率分别为62%、72%和95%。接受药物治疗的患者（n = 19）30天死亡率为100%。在接受手术治疗的患者（n = 45）中，1个月、1年和5年的生存率分别为71%、48%和32%。高血压病史、并发充血性心力衰竭以及年龄与不良预后相关。
尽管在药物和介入技术方面有所改进，但在这个当代系列研究中，早期和长期预后仍然很差。
