Guo Junming, Xiao Bingxiu, Liu Qiong, Gong Zhaohui, Le Yanping
School of Medicine, Ningbo University, Ningbo, China.
Cancer Invest. 2008 May;26(4):369-74. doi: 10.1080/07357900701788130.
Aloe-emodin is a hydroxyanthraquinone found in Aloe vera, as well as in leaves and roots of other plants. The mechanisms of its anticancer effect are largely unknown. The present study investigated its molecular mechanisms. Crystal violet assay showed that aloe-emodin had a long-term anti-proliferation effect on human gastric cancer MGC-803 and SGC-7901 cells. Scratch wound-healing motility assays indicated its anti-migration effect. Aloe-emodin arrested SGC-7901 cells at G2/M phase. More importantly, aloe-emodin inhibited the expressions of protein kinase C and c-myc. In conclusion, the anticancer effect of aloe-emodin on gastric cancer cells involves suppression of c-myc expression.
芦荟大黄素是一种在芦荟中以及其他植物的叶子和根部发现的羟基蒽醌。其抗癌作用机制在很大程度上尚不清楚。本研究调查了其分子机制。结晶紫测定表明，芦荟大黄素对人胃癌MGC - 803和SGC - 7901细胞具有长期的抗增殖作用。划痕伤口愈合运动测定表明其具有抗迁移作用。芦荟大黄素使SGC - 7901细胞停滞在G2/M期。更重要的是，芦荟大黄素抑制蛋白激酶C和c - myc的表达。总之，芦荟大黄素对胃癌细胞的抗癌作用涉及抑制c - myc表达。
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