The Ritchie Centre, Hudson Institute of Medical Research, Clayton 3168, Australia.
Department of Obstetrics and Gynaecology, Monash University, Clayton 3168, Australia.
Int J Mol Sci. 2021 Feb 8;22(4):1708. doi: 10.3390/ijms22041708.
Aloe vera (AV), a succulent plant belonging to the Liliaceae family, has been widely used for biomedical and pharmaceutical application. Its popularity stems from several of its bioactive components that have anti-oxidant, anti-microbial, anti-inflammatory and even immunomodulatory effects. Given such unique multi-modal biological impact, AV has been considered as a biomaterial for regenerative medicine and tissue engineering applications, where tissue repair and neo-angiogenesis are vital. This review outlines the growing scientific evidence that demonstrates the advantage of AV as tissue engineering scaffolds. We particularly highlight the recent advances in the application of AV-based scaffolds. From a tissue engineering perspective, it is pivotal that the implanted scaffolds strike an appropriate foreign body response to be well-accepted in the body without complications. Herein, we highlight the key cellular processes that regulate the foreign body response to implanted scaffolds and underline the immunomodulatory effects incurred by AV on the innate and adaptive system. Given that AV has several beneficial components, we discuss the importance of delving deeper into uncovering its action mechanism and thereby improving material design strategies for better tissue engineering constructs for biomedical applications.
库拉索芦荟（AV），百合科肉质植物，已广泛应用于生物医学和制药领域。其广泛应用源于其多种生物活性成分，具有抗氧化、抗菌、抗炎甚至免疫调节作用。鉴于其独特的多模式生物学影响，AV 已被认为是再生医学和组织工程应用的生物材料，组织修复和新血管生成至关重要。本综述概述了越来越多的科学证据，证明 AV 作为组织工程支架的优势。我们特别强调了基于 AV 的支架应用的最新进展。从组织工程的角度来看，植入的支架必须引起适当的异物反应，才能在体内被很好地接受而不会引起并发症。在此，我们强调调节植入支架异物反应的关键细胞过程，并强调 AV 对先天和适应性免疫系统的免疫调节作用。鉴于 AV 具有多种有益成分，我们讨论了深入研究其作用机制的重要性，从而改进材料设计策略，以更好地构建用于生物医学应用的组织工程结构。
