Manirakiza Astère, Irakoze Laurent, Manirakiza Sebastien
University Hospital Center of Kamenge, Burundi.
Chongqing Medical University.
East Afr Health Res J. 2021;5(1):1-16. doi: 10.24248/eahrj.v5i1.645. Epub 2021 Jun 11.
Many years ago, was cited to have a lot of therapeutic properties including; anti-microbial, anti-viral, anti-cancer, anti-oxidant, anti-inflammatory, skin protection, wound healing, and regulation of blood glucose and cholesterol. However, Aloe could present some side effects. This review focused on the latest discoveries regarding the therapeutic role of Aloe plant or its compounds on the acquired biological capabilities for tumour growth and progression namely; evading growth suppressor, avoiding immune destruction, enabling replicative immortality, tumour promoting inflammation, activating invasion and metastasis, inducing angiogenesis, genome instability and mutation, resisting cell death, deregulating cellular energetics and sustaining proliferating signalling. It clarified the anti-cancer activities it exerts on different types of cancer and also highlighted some pro-oncogenic pathways that can be disrupted by different compounds of Aloe.
许多年前，芦荟被认为具有多种治疗特性，包括抗菌、抗病毒、抗癌、抗氧化、抗炎、皮肤保护、伤口愈合以及调节血糖和胆固醇。然而，芦荟可能会有一些副作用。本综述聚焦于芦荟植物或其化合物在肿瘤生长和进展的获得性生物学能力方面治疗作用的最新发现，即逃避生长抑制、避免免疫破坏、实现复制永生、促进肿瘤炎症、激活侵袭和转移、诱导血管生成、基因组不稳定和突变、抵抗细胞死亡、失调细胞能量代谢以及维持增殖信号传导。它阐明了芦荟对不同类型癌症所发挥的抗癌活性，还强调了芦荟的不同化合物可能破坏的一些促癌途径。
