Berrocal Carmen, Ruiz Moreno Modesto A, Rando Miguel A, Benvenuti Antonella, Cassano Giovanni B
Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnologies, University of Pisa, Via Roma 67, Pisa 56126, Italy.
Psychiatry Res. 2008 Jun 30;159(3):300-7. doi: 10.1016/j.psychres.2007.10.002. Epub 2008 Apr 29.
Several lines of evidence have raised the question of whether Borderline Personality Disorder (BPD) is an independent disease entity or it might be better conceptualized as belonging to the spectrum of mood disorders. This study explores a wide array of lifetime mood features (mood, cognitions, energy, and rhythmicity and vegetative functions) in patients with BP and mood disorders. The sample consisted of 25 BPD patients who did not meet the criteria for bipolar disorders, 16 bipolar disorders patients who did not meet the criteria for BPD, 19 unipolar patients who did not meet the criteria for BPD, and 30 non-clinical subjects. Clinical diagnoses were determined by administering the structured clinical interviews for DSM-IV disorders. The Mood Spectrum Self-Report (MOODS-SR) was used for measuring lifetime mood phenomenology. Clinical subjects displayed higher mean scores than normal subjects in all domains of the MOODS-SR, and BPD patients displayed higher scores than unipolar patients in the Mood and Cognition depressive subdomains. Differences between patients with BP and bipolar disorders on MOODS psychopathology did not attain statistical significance for any (sub)domain considered. The results of this study are consistent with previous findings suggesting the importance of mood dysregulations in patients with BPD.
边缘型人格障碍（BPD）是一种独立的疾病实体，还是更适合被概念化为属于情绪障碍谱系。本研究探讨了BPD患者和情绪障碍患者广泛的终生情绪特征（情绪、认知、能量、节律性和植物神经功能）。样本包括25名不符合双相情感障碍标准的BPD患者、16名不符合BPD标准的双相情感障碍患者、19名不符合BPD标准的单相患者以及30名非临床受试者。临床诊断通过对DSM-IV障碍进行结构化临床访谈来确定。情绪谱系自评量表（MOODS-SR）用于测量终生情绪现象学。临床受试者在MOODS-SR的所有领域的平均得分均高于正常受试者，BPD患者在情绪和认知抑郁子领域的得分高于单相患者。在MOODS精神病理学方面，BPD患者和双相情感障碍患者之间在任何考虑的（子）领域均未达到统计学显著性差异。本研究结果与先前的研究结果一致，表明情绪调节障碍在BPD患者中的重要性。
