Masterton R G, Galloway A, French G, Street M, Armstrong J, Brown E, Cleverley J, Dilworth P, Fry C, Gascoigne A D, Knox Alan, Nathwani Dilip, Spencer Robert, Wilcox Mark
Department of Microbiology, Crosshouse Hospital, Kilmarnock, UK.
J Antimicrob Chemother. 2008 Jul;62(1):5-34. doi: 10.1093/jac/dkn162. Epub 2008 Apr 29.
These evidence-based guidelines have been produced after a systematic literature review of a range of issues involving prevention, diagnosis and treatment of hospital-acquired pneumonia (HAP). Prevention is structured into sections addressing general issues, equipment, patient procedures and the environment, whereas in treatment, the structure addresses the use of antimicrobials in prevention and treatment, adjunctive therapies and the application of clinical protocols. The sections dealing with diagnosis are presented against the clinical, radiological and microbiological diagnosis of HAP. Recommendations are also made upon the role of invasive sampling and quantitative microbiology of respiratory secretions in directing antibiotic therapy in HAP/ventilator-associated pneumonia.
这些循证指南是在对一系列涉及医院获得性肺炎(HAP)预防、诊断和治疗问题的文献进行系统综述后制定的。预防部分分为针对一般问题、设备、患者操作和环境等方面,而治疗部分则涉及抗菌药物在预防和治疗中的使用、辅助治疗以及临床方案的应用。关于诊断的部分是针对HAP的临床、影像学和微生物学诊断呈现的。还就侵入性采样和呼吸道分泌物定量微生物学在指导HAP/呼吸机相关性肺炎抗生素治疗中的作用提出了建议。