Dörr Marcus, Ruppert Jörg, Wallaschofski Henri, Felix Stephan B, Völzke Henry
Department of Internal Medicine B, Cardiology, Angiology and Pulmology, Ernst-Moritz-Arndt-University, Greifswald, Germany.
Endocr J. 2008 Jul;55(3):495-502. doi: 10.1507/endocrj.k07e-083. Epub 2008 Apr 30.
Thyroid dysfunction is associated with detrimental cardiovascular effects. We analyzed whether thyroid status is associated with aortic valve sclerosis (AVS) and mitral annular calcification (MAC) as markers of generalized atherosclerosis.
Data of 2065 subjects (923 women and 1142 men) aged > or =45 years from the Study of Health in Pomerania (SHIP) were analyzed with respect to low, medium and high TSH levels. Logistic regression models were adjusted for major confounders of atherosclerosis.
In women, the prevalence of AVS was the highest in those with low TSH (35.1% vs. 26.7% in medium TSH; p<0.05), while there was a higher prevalence of MAC in men with high TSH levels (9.2% vs. 5.2% in medium TSH; p<0.05). Compared with euthyroid men there was an increased adjusted odds ratio for MAC (OR 2.07; 95% CI 1.12-3.89, p<0.05), for the combination of AVS and MAC (OR 2.13; 95% CI 1.08-4.21, p<0.05) or for one of both (OR 1.47; 95% CI 1.02-2.13, p<0.05) among men with high TSH. No such association was found in women.
There was an association between thyroid function and valvular sclerosis. Men with high TSH values had increased odds for AVS or MAC, and the combination of both. These findings may reflect an increased atherosclerotic state in affected subjects.
甲状腺功能障碍与不良心血管效应相关。我们分析了甲状腺状态是否与作为全身动脉粥样硬化标志物的主动脉瓣硬化（AVS）和二尖瓣环钙化（MAC）相关。
对来自波美拉尼亚健康研究（SHIP）的2065名年龄≥45岁的受试者（923名女性和1142名男性）的数据进行分析，根据促甲状腺激素（TSH）水平分为低、中、高组。逻辑回归模型针对动脉粥样硬化的主要混杂因素进行了校正。
在女性中，TSH低的人群中AVS患病率最高（35.1%，而TSH中等的人群中为26.7%；p<0.05），而TSH高的男性中MAC患病率更高（9.2%，而TSH中等的人群中为5.2%；p<0.05）。与甲状腺功能正常的男性相比，TSH高的男性中MAC的校正比值比增加（比值比2.07；95%置信区间1.12 - 3.89，p<0.05），AVS和MAC联合出现的校正比值比增加（比值比2.13；95%置信区间1.08 - 4.21，p<0.05），或两者之一出现的校正比值比增加（比值比1.47；95%置信区间1.02 - 2.13，p<0.05）。在女性中未发现此类关联。
甲状腺功能与瓣膜硬化之间存在关联。TSH值高的男性发生AVS或MAC以及两者联合出现的几率增加。这些发现可能反映了受影响受试者动脉粥样硬化状态的增加。
