Institute for Community Medicine, University Medicine Greifswald, Walther Rathenau Str. 48, D-17475, Greifswald, Germany.
DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Eur Radiol. 2016 Dec;26(12):4490-4496. doi: 10.1007/s00330-016-4316-4. Epub 2016 Mar 14.
Our aim was to investigate the association of thyroid function defined by serum concentrations of thyroid-stimulating hormone (TSH) with thoracic aortic wall thickness (AWT) as a marker of atherosclerotic processes.
We pooled data of 2,679 individuals from two independent population-based surveys of the Study of Health in Pomerania. Aortic diameter and AWT measurements were performed on a 1.5-T MRI scanner at the concentration of the right pulmonary artery displaying the ascending and the descending aorta.
TSH, treated as continuous variable, was significantly associated with descending AWT (β = 0.11; 95 % confidence interval (CI) 0.02-0.21), while the association with ascending AWT was not statistically significant (β = 0.20; 95 % CI -0.01-0.21). High TSH (>3.29 mIU/L) was significantly associated with ascending (β = 0.12; 95 % CI 0.02-0.23) but not with descending AWT (β = 0.06; 95 % CI -0.04-0.16). There was no consistent association between TSH and aortic diameters.
Our study demonstrated that AWT values increase with increasing serum TSH concentrations. Thus, a hypothyroid state may be indicative for aortic atherosclerosis. These results fit very well to the findings of previous studies pointing towards increased atherosclerotic risk in the hypothyroid state.
• Serum TSH concentrations are positively associated with aortic wall thickness. • Serum TSH concentrations are not associated with the aortic diameters. • Serum 3,5-diiodothyronine concentrations may be positively associated with aortic wall thickness.
我们旨在研究血清促甲状腺激素（TSH）浓度定义的甲状腺功能与作为动脉粥样硬化过程标志物的胸主动脉壁厚度（AWT）之间的关联。
我们汇总了来自波罗的海健康研究的两项独立人群调查的 2679 名个体的数据。在显示升主动脉和降主动脉的右肺动脉浓度 1.5-T MRI 扫描仪上进行主动脉直径和 AWT 测量。
TSH 作为连续变量，与降主动脉 AWT 显著相关（β=0.11；95%置信区间（CI）0.02-0.21），而与升主动脉 AWT 的相关性无统计学意义（β=0.20；95%CI -0.01-0.21）。高 TSH（>3.29 mIU/L）与升主动脉显著相关（β=0.12；95%CI 0.02-0.23），但与降主动脉 AWT 不相关（β=0.06；95%CI -0.04-0.16）。TSH 与主动脉直径之间没有一致的关联。
我们的研究表明，AWT 值随着血清 TSH 浓度的增加而增加。因此，甲状腺功能减退状态可能表明主动脉粥样硬化。这些结果与先前研究的发现非常吻合，这些研究表明甲状腺功能减退状态下的动脉粥样硬化风险增加。
血清 TSH 浓度与主动脉壁厚度呈正相关。
血清 TSH 浓度与主动脉直径无关。
血清 3,5-二碘甲状腺原氨酸浓度可能与主动脉壁厚度呈正相关。
