Bisdas Sotirios, Surlan-Popovic Katarina, Didanovic Vojko, Vogl Thomas J
Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Hospital, Theodor Stern Kai 7, 60590 Frankfurt, Germany.
Eur Radiol. 2008 Oct;18(10):2241-50. doi: 10.1007/s00330-008-0990-1. Epub 2008 Apr 30.
Our purpose was to determine the repeatability of squamous cell cancer in head and neck (SCCHN) and muscle tissue vascularity measurements as well as the inter- and intra-observer agreement using dynamic contrast-enhanced (DCE) multi-detector CT (MDCT). Twelve patients with histologically proven SCCHN were twice examined within 46 h. Measurement error and repeatability were assessed for each of the four functional parameters using the Bland-Altman plots. Two independent observers recorded the vascularity values of the tumor tissue; inter- and intra-observer agreement was assessed using the Bland-Altman plot analysis and intraclass correlation coefficients. For the tumor, the mean difference (95% limits of agreement) was 0.40 ml/min/100 g tissue (-6.80, 9.60); 0.01 (-0.96, 0.97) ml/100 g tissue; 0.20 (-1.80, 2.30) s; and 0.40 (-2.00, 2.80) ml/min/100 g tissue for BF, BV, MTT, and PS, respectively. For the muscle, the mean difference (95% limits of agreement) was -0.18 (-1.70, 1.35), 0.04 (-1.17, 1.35), -0.10 (-5.80, 5.60), and -0.10 (-2.20, 2.00), respectively. Measurement changes of at least +/-8%, 30%, 36%, and 13% were found to be significant for BF, BV, MTT, and PS, respectively. There was better intra- than inter-observer agreement.
我们的目的是确定头颈部鳞状细胞癌（SCCHN）和肌肉组织血管测量的可重复性，以及使用动态对比增强（DCE）多排CT（MDCT）时观察者间和观察者内的一致性。12例经组织学证实为SCCHN的患者在46小时内接受了两次检查。使用Bland-Altman图评估四个功能参数中每个参数的测量误差和可重复性。两名独立观察者记录肿瘤组织的血管值；使用Bland-Altman图分析和组内相关系数评估观察者间和观察者内的一致性。对于肿瘤，平均差异（一致性界限的95%）分别为0.40 ml/min/100 g组织（-6.80，9.60）；0.01（-0.96，0.97）ml/100 g组织；0.20（-1.80，2.30）秒；以及0.40（-2.00，2.80）ml/min/100 g组织，分别对应血流灌注（BF）、血容量（BV）、平均通过时间（MTT）和通透性表面面积乘积（PS）。对于肌肉，平均差异（一致性界限的95%）分别为-0.18（-1.70，1.35）、0.04（-1.17，1.35）、-0.10（-5.80，5.60）和-0.10（-2.20，2.00）。发现BF、BV、MTT和PS的测量变化至少分别达到±8%、30%、36%和13%时具有显著性。观察者内一致性优于观察者间一致性。
