Krug A W, Ehrhart-Bornstein M
Carl Gustav Carus University Hospital, Department of Internal Medicine III, Dresden, Germany.
Horm Metab Res. 2008 Aug;40(8):515-7. doi: 10.1055/s-2008-1073154. Epub 2008 Apr 30.
Recently, it has become evident that the adrenals play a key role in obesity as well as in the metabolic syndrome and their complications. On the one hand, adrenal steroids are involved in physiological regulation of adipose tissue and energy homeostasis and in the pathogenesis of cardiometabolic complications. On the other hand, fat cell-derived factors, adipocytokines, and lipids released from adipose tissue are involved in the modulation of adrenal steroidogenesis. Aldosterone plasma levels are elevated in obesity and in patients with the metabolic syndrome. Recent research has provided evidence that adipocytes secrete factors that stimulate adrenal mineralocorticoid release and sensitize the adrenal cortex to angiotensin II.
最近，肾上腺在肥胖、代谢综合征及其并发症中发挥关键作用已变得显而易见。一方面，肾上腺类固醇参与脂肪组织的生理调节和能量稳态以及心脏代谢并发症的发病机制。另一方面，脂肪细胞衍生因子、脂肪细胞因子以及从脂肪组织释放的脂质参与肾上腺类固醇生成的调节。肥胖症患者和代谢综合征患者的醛固酮血浆水平升高。最近的研究已提供证据表明，脂肪细胞分泌刺激肾上腺盐皮质激素释放并使肾上腺皮质对血管紧张素II敏感的因子。
