Luini Alberto, Mironov Alexander A, De Matteis Maria Antonietta, Griffiths Gareth
Department Cell Biology and Oncology, Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro, Chieti, Italy.
Med Secoli. 2007;19(1):29-54.
The morpho-functional principles of secretory traffic are still unclear, in stark contrast with our advanced knowledge of the underlying molecular machineries. Recently, the conceptual and technological hindrances that have delayed progress in this area have been disappearing, and new glimpses of the organization of traffic in intact cells are being revealed by a cluster of powerful morphological techniques. Here, we discuss the new advances in the light of the three main possible traffic principles: by anterograde vesicles, progression/maturation, and flow via continuities.
分泌运输的形态功能原理仍不清楚，这与我们对其潜在分子机制的深入了解形成鲜明对比。最近，阻碍该领域进展的概念和技术障碍正在消失，一系列强大的形态学技术正在揭示完整细胞中运输组织的新情况。在此，我们根据三种主要的可能运输原理：通过顺行囊泡、进展/成熟以及通过连续性流动，来讨论这些新进展。
