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Neurobiological applications of small molecule screening.

作者信息

Bauer Andras, Stockwell Brent

机构信息

Columbia University, Department of Biological Sciences, 614 Fairchild Center, New York, New York 10027, USA.

出版信息

Chem Rev. 2008 May;108(5):1774-86. doi: 10.1021/cr0782372. Epub 2008 May 1.

DOI:10.1021/cr0782372
PMID:18447397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2712879/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79f/2712879/be5867909d06/nihms-123133-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79f/2712879/ef8741cb172a/nihms-123133-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79f/2712879/8ef431b7be02/nihms-123133-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79f/2712879/f50fc206d82c/nihms-123133-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79f/2712879/be5867909d06/nihms-123133-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79f/2712879/ef8741cb172a/nihms-123133-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79f/2712879/8ef431b7be02/nihms-123133-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79f/2712879/f50fc206d82c/nihms-123133-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79f/2712879/be5867909d06/nihms-123133-f0004.jpg

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本文引用的文献

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Challenges for blood-brain barrier (BBB) screening.血脑屏障（BBB）筛查面临的挑战。
Xenobiotica. 2007 Oct-Nov;37(10-11):1135-51. doi: 10.1080/00498250701570285.
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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.一种工程化人β2-肾上腺素能G蛋白偶联受体的高分辨率晶体结构
支架多样性合成产生复杂的、结构和功能各异的四环苯并吡喃。
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Integration of small-molecule discovery in academic biomedical research.小分子发现融入学术生物医学研究。
Mt Sinai J Med. 2010 Jul-Aug;77(4):350-7. doi: 10.1002/msj.20197.
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Synthesis at the interface of chemistry and biology.化学与生物学交叉领域的合成。
J Am Chem Soc. 2009 Sep 9;131(35):12497-515. doi: 10.1021/ja9026067.
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A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse.一种用于治疗亨廷顿舞蹈症的小分子治疗先导物：C2-8在R6/2转基因小鼠中的临床前药理学及疗效
Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16685-9. doi: 10.1073/pnas.0707842104. Epub 2007 Oct 9.
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Aptamer displacement identifies alternative small-molecule target sites that escape viral resistance.适体置换可识别逃避病毒抗性的替代性小分子靶位点。
Chem Biol. 2007 Jul;14(7):804-12. doi: 10.1016/j.chembiol.2007.06.003.
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A time-resolved fluorescence assay to identify small-molecule inhibitors of HIV-1 fusion.一种用于鉴定HIV-1融合小分子抑制剂的时间分辨荧光测定法。
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