Chevret S, Chastang C
Département d'informatique et de biostatistique médicale, Hôpital Saint-Louis, Paris, France.
Prog Urol. 1991 Apr;1(2):281-5.
The cardiovascular risk induced by oestrogen treatment appears to be minimal when oestrogens are prescribed at low doses (daily dose less than 3 mg/day) and when this drug is not prescribed in patients with a history of cardiovascular disease. The Prostatic Cancer Cooperative Study Group compared the course of 137 patients treated by oestrogens with a French male population matched for age: ten accidents were observed versus nine expected and one death was observed versus 3 expected. By selecting patients, oestrogens can therefore still be part of the range of treatments available for advanced prostatic cancer.
当以低剂量（每日剂量低于3毫克/天）开具雌激素处方时，以及当该药物不开给有心血管疾病史的患者时，雌激素治疗引起的心血管风险似乎极小。前列腺癌合作研究组将137名接受雌激素治疗的患者的病程与年龄匹配的法国男性人群进行了比较：观察到10起意外事件，而预期为9起，观察到1例死亡，而预期为3例。因此，通过选择患者，雌激素仍然可以成为晚期前列腺癌可用治疗方法的一部分。
