Khanna Geetika, Bushnell David, O'Dorisio M Sue
Department of Radiology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa 52242, USA.
Oncologist. 2008 Apr;13(4):382-9. doi: 10.1634/theoncologist.2007-0175.
In this paper, we review the pediatric oncologic applications of somatostatin receptor-targeted imaging and therapy. Somatostatin receptors are expressed in high densities by embryonal tumors, such as neuroblastoma and medulloblastoma, and neuroendocrine tumors like carcinoids and islet cell tumors. We first review the distribution of these receptors in normal tissues and tumor cells. We then discuss the technique of somatostatin receptor scintigraphy (SRS) in the pediatric population. Next, the specific clinical applications of SRS with regard to the imaging of neuroblastoma, central nervous system tumors, and gastroenteropancreatic neuroendocrine tumors of childhood are discussed. Finally, we discuss the potential role of somatostatin receptor-targeted radiotherapy for improving the duration and quality of life of children with these tumors.
在本文中，我们回顾了生长抑素受体靶向成像和治疗在儿科肿瘤学中的应用。胚胎性肿瘤如神经母细胞瘤和髓母细胞瘤以及类癌和胰岛细胞瘤等神经内分泌肿瘤中高密度表达生长抑素受体。我们首先回顾这些受体在正常组织和肿瘤细胞中的分布。然后我们讨论生长抑素受体闪烁显像（SRS）在儿科人群中的技术。接下来，讨论SRS在儿童神经母细胞瘤、中枢神经系统肿瘤和胃肠胰神经内分泌肿瘤成像方面的具体临床应用。最后，我们讨论生长抑素受体靶向放疗在改善患有这些肿瘤儿童的生存期和生活质量方面的潜在作用。
