Gilman Jodi M, Ramchandani Vijay A, Davis Megan B, Bjork James M, Hommer Daniel W
Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892, USA.
J Neurosci. 2008 Apr 30;28(18):4583-91. doi: 10.1523/JNEUROSCI.0086-08.2008.
People typically drink alcohol to induce euphoria or reduce anxiety, and they frequently drink in social settings, yet the effect of alcohol on human brain circuits involved in reward and emotion has been explored only sparingly. We administered alcohol intravenously to social drinkers while brain response to visual threatening and nonthreatening facial stimuli was measured using functional magnetic resonance imaging (fMRI). Alcohol robustly activated striatal reward circuits while attenuating response to fearful stimuli in visual and limbic regions. Self-ratings of intoxication correlated with striatal activation, suggesting that activation in this area may contribute to subjective experience of pleasure and reward during intoxication. These results show that the acute pharmacological rewarding and anxiolytic effects of alcohol can be measured with fMRI.
人们通常饮酒以诱导欣快感或减轻焦虑，且他们经常在社交场合饮酒，然而酒精对参与奖赏和情绪的人类脑回路的影响却鲜有研究。我们对社交饮酒者静脉注射酒精，同时使用功能磁共振成像（fMRI）测量大脑对视觉威胁性和非威胁性面部刺激的反应。酒精强烈激活纹状体奖赏回路，同时减弱视觉和边缘区域对恐惧刺激的反应。自我醉酒评分与纹状体激活相关，表明该区域的激活可能有助于醉酒期间愉悦和奖赏的主观体验。这些结果表明，酒精的急性药理学奖赏和抗焦虑作用可以通过fMRI来测量。
