McClatchey W, Snyderman R
Prostaglandins. 1976 Sep;12(3):415-26. doi: 10.1016/0090-6980(76)90022-8.
The effects of prostaglandins on human monocyte chemotaxis were studied in vitro. None of the prostaglandins tested, including members of the A, B, E or F series, were chemotactic for monocytes. Prostaglandin E2 however, enhanced the chemotactic responsiveness of monocytes to complement - activated human serum by almost 200%. The enhancement of chemotaxis was not directly related to the ability of PGE2 to raise intracellular cyclic AMP levels. These studies support a role for prostaglandins as modulators of the inflammatory response.
在体外研究了前列腺素对人单核细胞趋化性的影响。所测试的前列腺素，包括A、B、E或F系列的成员，均对单核细胞无趋化作用。然而，前列腺素E2可使单核细胞对补体激活的人血清的趋化反应性增强近200%。趋化作用的增强与PGE2升高细胞内环磷酸腺苷水平的能力无直接关系。这些研究支持前列腺素作为炎症反应调节剂的作用。
