Sereda Michal J, Hartmann Susanne, Lucius Richard
Department of Molecular Parasitology, Institute of Biology, Humboldt University Berlin, Philippstr. 13, Haus 14, Berlin, Germany.
Trends Parasitol. 2008 Jun;24(6):272-8. doi: 10.1016/j.pt.2008.03.006. Epub 2008 Apr 29.
Parasitic worms contain potent allergens, but epidemiological and experimental studies suggest that infections with certain helminths are negatively associated with the prevalence of allergic diseases. This seeming contradiction can be addressed by using filarial tropomyosin as an example. This protein shares structural features and crossreacting B-cell epitopes with other highly allergenic invertebrate tropomyosins. Nevertheless, it usually does not provoke allergic disease in infected individuals. In addition, it is one of the most prominent candidates for an anti-nematode vaccine. Recent data suggest mechanisms that might prevent hosts from developing allergic reactions against allergens of their parasites, such as filarial tropomyosin.
寄生虫含有强效过敏原，但流行病学和实验研究表明，某些蠕虫感染与过敏性疾病的患病率呈负相关。以丝虫原肌球蛋白为例可以解释这一看似矛盾的现象。这种蛋白质与其他高度致敏的无脊椎动物原肌球蛋白具有共同的结构特征和交叉反应性B细胞表位。然而，它通常不会在受感染个体中引发过敏性疾病。此外，它是抗线虫疫苗最突出的候选物之一。最近的数据表明了一些机制，这些机制可能会阻止宿主对其寄生虫的过敏原（如丝虫原肌球蛋白）产生过敏反应。
