Becerra E, Aranguiz E, Pedemonte O, De Prada M T, Merello L, Orfali C, Aninat M, Torres H, González R, Chadid P
Servicio de Cirugía Cardiovascular, Hospital Dr Gustavo Fricke, Viña del Mar, Chile.
Rev Med Chil. 1991 Sep;119(9):1038-42.
Use of cyclosporin A has improved survival in patients submitted to cardiac transplantation. However, high cost of cyclosporin poses a problem for many patients in Chile. Ketoconazole is able to reduce hepatic metabolism of cyclosporin and thus prolong therapeutic levels. A 74 to 82% reduction in cyclosporin requirements was obtained in a cardiac transplant patient by adding ketoconazole. No renal damage was detected. Therefore, this drug association may help extend cardiac transplantation programs in Chile.
环孢素A的使用提高了接受心脏移植患者的生存率。然而，环孢素的高成本给智利的许多患者带来了问题。酮康唑能够降低环孢素的肝脏代谢，从而延长治疗水平。通过添加酮康唑，一名心脏移植患者的环孢素需求量降低了74%至82%。未检测到肾脏损伤。因此，这种药物联合使用可能有助于扩大智利的心脏移植项目。
