Berkovitch M, Bitzan M, Matsui D, Finkelstein H, Balfe J W, Koren G
Department of Pharmacy, Hospital for Sick Children, Toronto, Canada.
Pediatr Nephrol. 1994 Aug;8(4):492-3. doi: 10.1007/BF00856546.
Ketoconazole is known to inhibit the metabolism of cyclosporin through inhibition of cytochrome P-450. This pharmacological interaction was used in an 8-year-old renal transplant patient to successfully achieve therapeutic cyclosporin blood concentrations. The addition of ketoconazole to the cyclosporin regimen should be considered when difficulties are encountered in attaining satisfactory cyclosporin levels.
已知酮康唑可通过抑制细胞色素P - 450来抑制环孢素的代谢。这种药理相互作用被应用于一名8岁的肾移植患者，成功达到了环孢素的治疗性血药浓度。当在达到满意的环孢素水平遇到困难时，应考虑在环孢素治疗方案中添加酮康唑。
