1999财年至2006财年退伍军人事务部（VA）中抗精神病药物在精神分裂症门诊患者治疗中的使用情况。

Antipsychotic use in the treatment of outpatients with schizophrenia in the VA from fiscal years 1999 to 2006.

作者信息

Sernyak Michael J, Rosenheck Robert A

机构信息

Department of Psychiatry, Yale University, New Haven, CT 06516, USA.

出版信息

Psychiatr Serv. 2008 May;59(5):567-9. doi: 10.1176/ps.2008.59.5.567.

DOI:10.1176/ps.2008.59.5.567

PMID:18451019

Abstract

OBJECTIVE

This study examined changes in prescribing patterns of antipsychotic medications to treat schizophrenia.

METHODS

Pharmacy records for patients with schizophrenia were obtained from Department of Veterans Affairs databases. The proportion of patients prescribed specific second-generation antipsychotics or any first-generation antipsychotic was calculated per year.

RESULTS

In fiscal year (FY) 2006, 78,849 veterans with schizophrenia were prescribed antipsychotic medication. For FY 1999 to FY 2006 the percentage of patients with schizophrenia who received first-generation antipsychotics decreased from 40.8% to 15.9%, but the percentage receiving olanzapine, after peaking at 32.0% in FY 2001, decreased to 19.0%. The percentage of patients given quetiapine increased from 2.5% to 18.8%; risperidone, from 25.5% to 29.7%. However, clozapine usage remained flat, at 2.0%-3.0%. Use of then-new ziprasidone and aripiprazole rose from 5.0% to 9.0%.

CONCLUSIONS

Use of each antipsychotic newly marketed over eight years increased while use of risperidone was unchanged and use of olanzapine and the first-generation antipsychotics declined.

摘要

目的

本研究调查了用于治疗精神分裂症的抗精神病药物处方模式的变化。

方法

从退伍军人事务部数据库获取精神分裂症患者的药房记录。每年计算使用特定第二代抗精神病药物或任何第一代抗精神病药物的患者比例。

结果

2006财年，78849名患有精神分裂症的退伍军人接受了抗精神病药物治疗。在1999财年至2006财年期间，接受第一代抗精神病药物治疗的精神分裂症患者比例从40.8%降至15.9%，但接受奥氮平治疗的患者比例在2001财年达到32.0%的峰值后降至19.0%。接受喹硫平治疗的患者比例从2.5%增至18.8%；接受利培酮治疗的患者比例从25.5%增至29.7%。然而，氯氮平的使用保持平稳，为2.0%-3.0%。新上市的齐拉西酮和阿立哌唑的使用比例从5.0%增至9.0%。