Bauer J
Psychiatrische Universitätsklinik, Universität Freiburg, Germany.
Biotechnol Ther. 1991;2(3-4):285-98.
The biology of interleukin-6 (IL-6) has been extensively reviewed. This article therefore does not repeat in detail how this molecule was discovered and its cDNA cloned, or the molecular mechanisms of its synthesis, its structural features, and its basic biological functions. Instead, three questions are addressed more closely: (i) How is IL-6 involved in various disease states? (ii) Can IL-6 be useful as a diagnostic clinical marker? (iii) Are there good reasons to expect that IL-6, IL-6 derivatives or IL-6 antagonists may eventually be utilized as therapeutic agents?
白细胞介素-6（IL-6）的生物学特性已得到广泛综述。因此，本文不再详细重复该分子是如何被发现及其cDNA如何被克隆，也不再赘述其合成的分子机制、结构特征和基本生物学功能。相反，将更深入地探讨三个问题：（i）IL-6如何参与各种疾病状态？（ii）IL-6能否作为临床诊断标志物？（iii）是否有充分理由期望IL-6、IL-6衍生物或IL-6拮抗剂最终可用作治疗药物？
