Assimakopoulos Konstantinos, Karaivazoglou Katerina, Skokou Maria, Kalogeropoulou Marina, Kolios Panagiotis, Gourzis Philippos, Patrinos George P, Tsermpini Evangelia Eirini
Department of Psychiatry, School of Medicine, University of Patras, Rion, Patras 26504, Greece.
Department of Pharmacy, School of Health Sciences, University of Patras, Rion, Patras 26404, Greece.
Medicines (Basel). 2018 Mar 24;5(2):27. doi: 10.3390/medicines5020027.
Schizophrenic patients commonly suffer from sleep disorders which are associated with acute disease severity, worsening prognoses and a poorer quality of life. Research is attempting to disentangle the complex interplay between schizophrenia and sleep disturbances by focusing not only on demographic and clinical characteristics, but also on the identification of genetic factors. Here, we performed a systematic literature review on the topic of genetic variations in sleep-disordered schizophrenic patients in an attempt to identify high quality investigations reporting scientifically sound and clinically useful data. For this purpose, we conducted a thorough search of PubMed, ScienceDirect and GoogleScholar databases, according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) protocol. Our search yielded 11 eligible studies. Certain genetic variations were reported to be associated with schizophrenia-related sleep disorders. Antipsychotic-induced restless legs syndrome was linked to polymorphisms located on , , , and genes, clozapine-induced somnolence was correlated with polymorphisms of gene, while insomnia was associated with variants of the gene. There are significant genetic associations between schizophrenia and co-morbid sleep disorders, implicating the circadian system, dopamine and histamine metabolism and signal transduction pathways.
精神分裂症患者通常患有睡眠障碍，这些睡眠障碍与急性疾病严重程度、预后恶化和较差的生活质量相关。研究不仅关注人口统计学和临床特征，还致力于通过识别遗传因素来厘清精神分裂症与睡眠障碍之间复杂的相互作用。在此，我们针对睡眠障碍型精神分裂症患者的基因变异主题进行了一项系统的文献综述，试图识别出报告科学合理且临床有用数据的高质量研究。为此，我们根据系统评价和Meta分析的首选报告项目（PRISMA）方案的指南，对PubMed、ScienceDirect和GoogleScholar数据库进行了全面搜索。我们的搜索产生了11项符合条件的研究。据报道，某些基因变异与精神分裂症相关的睡眠障碍有关。抗精神病药物引起的不安腿综合征与位于 、 、 和 基因上的多态性有关，氯氮平引起的嗜睡与 基因的多态性相关，而失眠与 基因的变异有关。精神分裂症与共病睡眠障碍之间存在显著的基因关联，涉及昼夜节律系统、多巴胺和组胺代谢以及信号转导通路。
