Kang Seung-Gul, Lee Yu Jin, Park Young-Min, Kim Leen, Lee Heon-Jeong
Department of Psychiatry, Gil Medical Center, Gachon University School of Medicine, Incheon, Republic of Korea.
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
Psychiatry Investig. 2018 Jan;15(1):84-89. doi: 10.4306/pi.2018.15.1.84. Epub 2018 Jan 16.
Restless legs syndrome (RLS) is considered a genetic disease and, following a genome-wide association study conducted in 2007, the mitogen-activated protein kinase 5 (MAP2K5) gene has been regarded as the promising candidate gene for RLS. The present study investigated whether polymorphisms of are associated with antipsychotics-induced RLS in schizophrenia.
We assessed antipsychotics-induced RLS symptoms in 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group. Five single-nucleotide polymorphisms (SNPs) of were genotyped. We investigated genetic and haplotypic associations of these five SNPs with the risk of antipsychotics-induced RLS symptoms.
We divided the 190 subjects into 2 groups: 1) those with RLS symptoms (n=96) and 2) those without RLS symptoms (n=94). There were no significant intergroup differences in the distributions of the genotypes and alleles of the rs1026732, rs11635424, rs12593813, rs4489954, and rs3784709 SNPs. However, the haplotype analysis showed that the G-G-G-G-T (rs1026732-rs11635424-rs12593813-rs4489954-rs3784709) haplotype was associated with RLS symptoms (permutation p=0.033).
These data suggest that a haplotype of polymorphisms confers increased susceptibility to antipsychotics-induced RLS symptoms in schizophrenic patients.
不宁腿综合征（RLS）被认为是一种遗传性疾病，在2007年进行全基因组关联研究后，丝裂原活化蛋白激酶5（MAP2K5）基因被视为RLS的有前景的候选基因。本研究调查了该基因的多态性是否与精神分裂症患者中抗精神病药物诱发的RLS相关。
我们使用国际不宁腿综合征研究组的诊断标准，评估了190名韩国精神分裂症患者中抗精神病药物诱发的RLS症状。对该基因的五个单核苷酸多态性（SNP）进行基因分型。我们研究了这五个SNP的基因和单倍型与抗精神病药物诱发的RLS症状风险之间的关联。
我们将190名受试者分为两组：1）有RLS症状的患者（n = 96）和2）无RLS症状的患者（n = 94）。rs1026732、rs11635424、rs12593813、rs4489954和rs3784709这几个SNP的基因型和等位基因分布在两组之间没有显著差异。然而，单倍型分析显示，G-G-G-G-T（rs1026732-rs11635424-rs12593813-rs4489954-rs3784709）单倍型与RLS症状相关（置换p = 0.033）。
这些数据表明，该基因多态性的一种单倍型使精神分裂症患者对抗精神病药物诱发的RLS症状易感性增加。
