微阵列在癌症研究中的临床应用。
Clinical uses of microarrays in cancer research.
作者信息
Virtanen Carl, Woodgett James
机构信息
University Health Network, Microarray Centre, Toronto Medical Discovery Tower, Toronto, Ontario, Canada.
出版信息
Methods Mol Med. 2008;141:87-113. doi: 10.1007/978-1-60327-148-6_6.
Abstract
Perturbations in genes play a key role in the pathogenesis of cancer. Microarray-based technology is an ideal way in which to study the effects and interactions of multiple genes in cancer. There are many technologic challenges in running a microarray study, including annotation of genes likely to be involved, designing the appropriate experiment, and ensuring adequate quality assurance steps are implemented. Once data are normalized, they need to be analyzed; and for this, there are numerous software packages and approaches.
摘要
基因扰动在癌症发病机制中起关键作用。基于微阵列的技术是研究癌症中多个基因的作用及相互作用的理想方法。进行微阵列研究存在许多技术挑战，包括对可能涉及的基因进行注释、设计合适的实验以及确保实施充分的质量保证步骤。一旦数据被标准化，就需要对其进行分析；为此，有众多软件包和方法。
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