Narsani Ashok Kumar, Jatoi Shafi Muhammad, Gul Siddiqa, Dabir Syed Asher
Department of Ophthalmology, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh.
J Coll Physicians Surg Pak. 2008 Feb;18(2):98-101.
To assess the efficacy of intravitreal ceftazidime in acute postoperative endophthalmitis.
Quasi experimental study.
Department of Ophthalmology Unit I, Eye Hospital, Liaquat University of Medical and Health Sciences, Hyderabad, from November 2004 to November 2006.
Twenty-one eyes of 21 patients of acute postoperative endophthalmitis were treated with intravitreal antibiotic ceftazidime. The inclusion criteria of the patients was the clinical diagnosis of acute postoperative endophthalmitis within 15 days of postoperative period with visual acuity better than or equal to hand movement close to face. After enrollment, vitreous tap was carried out in all cases followed by intravitreal ceftazidime injection. The outcome was measured in terms of clinical resolution of endophthalmitis and postresolution best corrected visual acuity. Mean of difference was tested by paired t-test.
Nineteen eyes (90.5%) responded to intravitreal ceftazidime therapy alone, while an additional pars plana vitrectomy was required in one eye. Sixteen eyes (84%) retained a visual acuity of 6/60 or better at 3 months after the initiation of the therapy (p<0.001). Retinal detachment developed in one eye receiving intravitreal therapy.
Ceftazidime was effective as intravitreal therapy for the management of acute postoperative endophthalmitis.
评估玻璃体内注射头孢他啶治疗急性术后眼内炎的疗效。
准实验研究。
2004年11月至2006年11月，海得拉巴利亚卡特医学与健康科学大学眼科医院第一眼科单元。
21例急性术后眼内炎患者的21只眼接受玻璃体内抗生素头孢他啶治疗。患者的纳入标准为术后15天内临床诊断为急性术后眼内炎，视力优于或等于眼前手动。入组后，所有病例均进行玻璃体穿刺，然后注射玻璃体内头孢他啶。根据眼内炎的临床消退情况和消退后的最佳矫正视力来衡量结果。差异均值采用配对t检验。
19只眼（90.5%）仅对玻璃体内注射头孢他啶治疗有反应，而1只眼需要额外进行玻璃体切割术。16只眼（84%）在治疗开始后3个月时视力保持在6/60或更好（p<0.001）。接受玻璃体内治疗的1只眼发生了视网膜脱离。
头孢他啶作为玻璃体内治疗药物对急性术后眼内炎的治疗有效。
