静脉输注肝素后出现的严重高甘油三酯血症。

Extreme hypertriglyceridemia following intravenous heparin infusion.

作者信息

Al Riyami Nafila B, Frohlich Jiri

机构信息

Department of Medical Biochemistry, University of British Columbia, St Paul's Hospital, Vancouver, Canada V6Z 1Y6.

出版信息

Clin Biochem. 2008 Jul;41(10-11):907-9. doi: 10.1016/j.clinbiochem.2008.04.004. Epub 2008 Apr 18.

DOI:10.1016/j.clinbiochem.2008.04.004

PMID:18454939

Abstract

We report a case of unexpected extreme hypertriglyceridemia in a 32 year old man following 5 days of intravenous heparin infusion. We believe the cause of the elevation is mainly due to a temporary depletion of lipoprotein lipase caused by heparin. To the best of our knowledge, this is the first case report of such an extreme elevation in triglycerides following prolonged intravenous heparin infusion. The clinical history and details of the suggested mechanism of the hypertriglyceridemia are discussed in this case report.

摘要

我们报告了一例32岁男性在静脉输注肝素5天后出现意外的极度高甘油三酯血症的病例。我们认为甘油三酯升高的原因主要是肝素导致脂蛋白脂肪酶暂时耗竭。据我们所知，这是首例关于长期静脉输注肝素后甘油三酯如此极度升高的病例报告。本病例报告讨论了高甘油三酯血症的临床病史及推测机制的细节。