长期肝素化导致的脂蛋白脂肪酶缺乏在孕期表现为严重高甘油三酯血症。
Lipoprotein lipase deficiency due to long-term heparinization presenting as severe hypertriglyceridaemia in pregnancy.
作者信息
Watts G F, Cameron J, Henderson A, Richmond W
机构信息
Department of Endocrinology and Chemical Pathology, United Medical School of Guy's Hospital, London, UK.
出版信息
Postgrad Med J. 1991 Dec;67(794):1062-4. doi: 10.1136/pgmj.67.794.1062.
Abstract
A case of severe hypertriglyceridaemia presenting in the third trimester of pregnancy in a woman on long-term heparin prophylaxis is described. The hypertriglyceridaemia was attributed to impaired clearance of triglyceride-rich lipoprotein particles secondary to heparin-induced reduction in the activity of the lipolytic enzyme, lipoprotein lipase.
摘要
本文描述了一例在长期接受肝素预防性治疗的女性患者妊娠晚期出现严重高甘油三酯血症的病例。高甘油三酯血症归因于富含甘油三酯的脂蛋白颗粒清除受损，这是由于肝素诱导脂解酶脂蛋白脂肪酶活性降低所致。
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