Dreier Jens, Vollmer Tanja, Freytag Claudia Christine, Bäumer Dietrich, Körfer Reiner, Kleesiek Knut
Institut für Laboratoriums und Transfusionsmedizin, Herz und Diabeteszentrum Nordrhein-Westfalen, 32545 Bad Oeynhausen, Germany.
Diagn Microbiol Infect Dis. 2008 Aug;61(4):476-83. doi: 10.1016/j.diagmicrobio.2008.03.008. Epub 2008 May 1.
Bartonella spp. are rare pathogens in humans and were recently recognized as important causative agents of culture-negative endocarditis. Here, we describe the 1st 2 documented cases of culture-negative endocarditis due to Bartonella henselae and Bartonella quintana encountered in a single hospital in Germany. Infection of the heart valve tissue was detected by broad-range polymerase chain reaction (PCR) and further confirmed by serologic testing. In particular, acute B. henselae infection with an impressive bacterial colonization of the infected cardiac valve was illustrated by transmission electron microscopy. B. henselae was further characterized by PCR assays targeting genotype-specific regions. Disease progression was initially monitored over the entire infection episode through inflammatory markers. In addition, a short overview of published detailed cases of Bartonella endocarditis in Europe within the last 7 years is given.
巴尔通体属是人类罕见的病原体，最近被确认为血培养阴性的心内膜炎的重要病原体。在此，我们描述了德国一家医院遇到的首例2例由亨氏巴尔通体和五日热巴尔通体引起的血培养阴性的心内膜炎病例。通过广谱聚合酶链反应（PCR）检测心脏瓣膜组织感染，并通过血清学检测进一步证实。特别是，通过透射电子显微镜显示了急性亨氏巴尔通体感染，感染的心脏瓣膜上有大量细菌定植。通过针对基因型特异性区域的PCR检测对亨氏巴尔通体进行了进一步鉴定。最初通过炎症标志物在整个感染过程中监测疾病进展。此外，还简要概述了过去7年欧洲已发表的巴尔通体心内膜炎详细病例。
