Andreu-Ballester J C, Pérez-Griera J, Ballester F, Colomer-Rubio E, Ortiz-Tarín I, Pelayo V, Rodero M, Cuéllar C
Emergency Department, Arnau de Vilanova Hospital, Valencia, Spain.
Exp Parasitol. 2008 Jul;119(3):433-6. doi: 10.1016/j.exppara.2008.03.014. Epub 2008 Apr 8.
High prevalence and intensity of infection with anisakid larvae has been reported in commercially important fish in Spain. Likewise, Kudoa-infected fish have lately been detected in both fresh and frozen fish. In the present study the possible relation between appendectomy and specific antibodies to these fish parasites was investigated. One hundred and sixty patients were enrolled in this study. They were divided into two groups of eighty patients each and matched for sex and age: Group 1 (appendectomized) and Group 2 (control group). Total immunoglobulins (Ig's), IgG, IgM, IgA and IgE against Anisakis simplex or Kudoa sp. antigens were analysed by ELISA. The mean values of the specific antibodies were lower in the appendectomy group, although significant differences were not observed in the case of IgG, IgA and IgE anti-A. simplex and IgE anti-Kudoa sp. In summary, appendectomy significantly decreased serum specific immunoglobulin levels against these food borne parasite antigens. This decrease was detectable from three months to three years post-appendectomy. It is necessary to study the influence of the surgical removal of other important parts of the GALT on these anti-parasite humoral immune responses.
西班牙商业上重要的鱼类中已报告了异尖线虫幼虫的高感染率和高强度感染。同样，最近在新鲜和冷冻鱼中都检测到了感染库道虫的鱼。在本研究中，调查了阑尾切除术与这些鱼类寄生虫特异性抗体之间的可能关系。本研究招募了160名患者。他们被分为两组，每组80名患者，并按性别和年龄进行匹配：第1组（阑尾切除组）和第2组（对照组）。通过ELISA分析针对简单异尖线虫或库道虫属抗原的总免疫球蛋白（Ig）、IgG、IgM、IgA和IgE。阑尾切除组中特异性抗体的平均值较低，尽管在抗简单异尖线虫IgG、IgA和IgE以及抗库道虫属IgE的情况下未观察到显著差异。总之，阑尾切除术显著降低了针对这些食源性寄生虫抗原的血清特异性免疫球蛋白水平。这种降低在阑尾切除术后3个月至3年都可检测到。有必要研究肠道相关淋巴组织其他重要部分的手术切除对这些抗寄生虫体液免疫反应的影响。
