Andreu-Ballester J C, Ballester F, Pérez-Griera J, Amigo V, Peñarroja-Otero C, Colomer-Rubio E, Ortiz-Tarín I, Pelayo V, García-Hernández P, Rodero M, Cuéllar C
Emergency Department, Arnau de Vilanova Hospital, 46015 Valencia, Spain.
Parasitol Int. 2009 Dec;58(4):401-5. doi: 10.1016/j.parint.2009.08.002. Epub 2009 Aug 13.
We found an association between tonsillectomized patients and subsequent appendicitis. We also observed that MALTectomy significantly decreased secretory IgA levels in serum of patients, being this decrease more pronounced when both operations (tonsillectomy and appendectomy) had been performed. The elevated humoral responses detected previously by us in BALB/c mice immunized with Kudoa sp. pseudocyst extracts and the high IgG1 and IgE levels induced by the oral administration of Kudoa sp. pseudocysts to BALB/c mice showed the possible immunopathological effects in man from the ingestion of Kudoa sp. infected fish. We use the ELISA method to investigate the possible relationship between MALTectomy (tonsillectomy and appendectomy) and specific antibody levels to Kudoa sp. Both anti-Kudoa sp. specific antibody levels and the number of patients that recognized Kudoa sp. antigens were greater in tonsillectomy patients when compared to the control and the other studied groups (appendectomized and appendectomized+tonsillectomies patients). Tonsillectomy was associated to a switch in the class of immunoglobulins involved in these responses and these responses may be abrogated by appendectomy. Tonsils and appendix may respond in different ways to Kudoa sp. antigens and these different reactions may be involved in some immunopathological reactions.
我们发现扁桃体切除患者与随后发生的阑尾炎之间存在关联。我们还观察到，黏膜相关淋巴组织切除显著降低了患者血清中的分泌型IgA水平，当同时进行扁桃体切除术和阑尾切除术这两种手术时，这种降低更为明显。我们之前在用库道虫属假囊肿提取物免疫的BALB/c小鼠中检测到的体液免疫反应升高，以及通过向BALB/c小鼠口服库道虫属假囊肿诱导的高IgG1和IgE水平，表明食用感染库道虫属的鱼类可能对人类产生免疫病理影响。我们使用酶联免疫吸附测定（ELISA）方法来研究黏膜相关淋巴组织切除（扁桃体切除术和阑尾切除术）与针对库道虫属的特异性抗体水平之间的可能关系。与对照组和其他研究组（阑尾切除患者和阑尾切除+扁桃体切除患者）相比，扁桃体切除患者中抗库道虫属特异性抗体水平以及识别库道虫属抗原的患者数量均更高。扁桃体切除术与这些反应中涉及的免疫球蛋白类别转换有关，而阑尾切除术可能会消除这些反应。扁桃体和阑尾可能对库道虫属抗原产生不同的反应，这些不同反应可能参与了某些免疫病理反应。
