Grant G A, Barlow J A, Leach K E
Strahlentherapie. 1976 Sep;152(3):285-91.
The administratio prior to irradiation of adenosine triphosphate (ATP) or other adenosine nucleotides, singly or in combination, increased the radioresistance of mice. Post-irradiation treatment with the adenosine nucleotides had no effect on the survival of the irradiated mice. Dose reduction factors of 2.32 could be obtained by pretreatment of mice with the following combination of protective agents: S-2(4-aminobutylamino)ethyl phosphorothioic acid(WR 2822), cysteamine (MEA) and ATP. Since cyclic AMP levels were unchangd in the spleen or gut by administration of cysteamine and other protectors it is unlikely that the increase in preotection was due to changes in cyclic AMP levles. The calcium salt of ATP provided a higher level of protection than the ATP alone, indicating that the protective mechanism of ATP is probably not related to anoxia.
在照射前单独或联合给予三磷酸腺苷（ATP）或其他腺苷核苷酸，可提高小鼠的辐射抗性。照射后用腺苷核苷酸处理对受照射小鼠的存活没有影响。通过用以下保护剂组合对小鼠进行预处理，可获得2.32的剂量降低因子：S-2（4-氨基丁基氨基）乙基硫代磷酸（WR 2822）、半胱胺（MEA）和ATP。由于给予半胱胺和其他保护剂后，脾脏或肠道中的环磷酸腺苷水平未发生变化，因此保护作用的增加不太可能是由于环磷酸腺苷水平的变化。ATP的钙盐比单独的ATP提供了更高水平的保护，这表明ATP的保护机制可能与缺氧无关。
