Szepietowski T, Ujec M, Falkiewicz K, Bielanow T, Szczepański A
Pol Tyg Lek. 1991;46(4-5):84-6.
A 30-year old female underwent kidney transplantation after unsuccessful 3-year dialysis for renal cortex necrosis. Immunosuppression was achieved with cyclosporin followed by azathioprine with prednisone. The patient conceived after 22 months with kidney transplantation. Mild decrease in arterial blood pressure and marked increased in glomerular filtration rate were seen during the first three months of pregnancy. Arterial blood pressure increased but insignificantly at the end of pregnancy. That time, gradual decrease in creatinine clearance was observed. An increase in serum bilirubin and alkaline phosphatase was noted. Pregnancy was terminated by cesarean section on the 38th week. Newborn was female, full-termed, viable, with body weight of 3,300 g. All examined parameters were normalized after delivery. Described case indicates that transplanted kidney functioning during pregnancy is similar to that in healthy women.
一名30岁女性因肾皮质坏死进行了3年透析治疗失败后接受了肾移植。免疫抑制采用环孢素，随后加用硫唑嘌呤和泼尼松。该患者肾移植22个月后怀孕。孕期前三个月动脉血压轻度下降，肾小球滤过率显著升高。妊娠末期动脉血压升高但不明显。此时，肌酐清除率逐渐下降。血清胆红素和碱性磷酸酶升高。妊娠38周时行剖宫产终止妊娠。新生儿为女性，足月，存活，体重3300克。产后所有检查参数均恢复正常。所述病例表明，移植肾在孕期的功能与健康女性相似。
