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[儿童霍奇金病第二次缓解期的持续时间。波兰儿童白血病和恶性淋巴瘤治疗组的治疗结果]

[Duration of second remission of Hodgkin's disease in children. Results of treatment achieved by the Polish Leukemia and Malignant Lymphoma Therapy in Children Group].

作者信息

Balwierz W, Armata J, Moryl-Bujakowska A, Depowska T, Radwańska U, Kaczmarek M, Ochocka M, Stańczak E, Sońta-Jakimczyk D, Bogusławska-Jaworska J

机构信息

Kliniki Hematologii Dzieciecej Instytutu Pediatrii AM w Krakowie.

出版信息

Pol Tyg Lek. 1991;46(48-49):924-8.

PMID:1845709
Abstract

Recurrence was noted in 18.5% of 194 children, in which chemotherapy with MVPP regimen produced complete I remission. In 6 out of 36 children with recurrent disease MVPP regimen was repeated, while the remaining children were treated with B-DOPA alone or combined with MOPP regimen. Local radiotherapy was used in 17 children. The second complete remission was achieved in 30 (83.7%) children. Thirteen out of 36 patients died because of the progress of the disease (11 children), and for complications (2 children). Percentage of persisting 5- and 10-year II remissions are 58.2% and 54.6%, respectively. A 5- and 10-year survival rates in children with recurrent disease are 80.5% and 60.5%, respectively. Our relatively favourable results we associate--first of all--with the chemotherapy intensity.

摘要

194名儿童中有18.5%出现复发,其中采用MVPP方案化疗后实现了完全缓解。36名复发患儿中有6名重复使用MVPP方案,其余患儿单独使用B-DOPA或联合MOPP方案治疗。17名儿童接受了局部放疗。30名(83.7%)儿童实现了第二次完全缓解。36名患者中有13名因疾病进展(11名儿童)和并发症(2名儿童)死亡。持续5年和10年第二次缓解的比例分别为58.2%和54.6%。复发疾病患儿的5年和10年生存率分别为80.5%和60.5%。我们相对较好的结果首先与化疗强度有关。

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