Kanaev S V, Gershanovich M L, Malinin A P, Kholin A V
Vopr Onkol. 1988;34(4):438-45.
The results of treatment of 92 cases of stage IIIB Hodgkin's disease were evaluated. Combined treatment (46) included 3-4 courses of MOPP (embichin, vincristine, natulan and prednisolone) followed by radical radiotherapy 2-4 weeks later. Complete remission was recorded in 36 (78.3%) out of 46 patients. Overall 5-year survival in that group was 75.3 +/- 7.8% matched by 95.8 +/- 4.2% in those in complete remission (36). No signs of recurrence were observed in 68.0 +/- 11.1% in the latter group during the 5 years of follow-up. Combination chemotherapy (MOPP) alone was given to 46 patients. Complete remission was registered in 43.5% of those patients which was significantly less frequent than in the combined therapy group (78.3%). Overall 5-year survival was 53.8 +/- 8.6% and recurrence-free course--in 58.1 +/- 11.7%. Overall survival and complete remission rate in the combined treatment group were shown to be significantly higher than in the patients who had received 5-6 courses of MOPP alone.
对92例IIIB期霍奇金病的治疗结果进行了评估。联合治疗（46例）包括3 - 4个疗程的MOPP方案（氮芥、长春新碱、甲基苄肼和泼尼松龙），随后在2 - 4周后进行根治性放疗。46例患者中有36例（78.3%）达到完全缓解。该组患者的总体5年生存率为75.3±7.8%，完全缓解患者（36例）的5年生存率为95.8±4.2%。在随访的5年中，后一组患者中有68.0±11.1%未观察到复发迹象。46例患者仅接受联合化疗（MOPP）。这些患者中有43.5%达到完全缓解，这一比例明显低于联合治疗组（78.3%）。总体5年生存率为53.8±8.6%，无复发生存率为58.1±11.7%。联合治疗组的总体生存率和完全缓解率显著高于仅接受5 - 6个疗程MOPP方案的患者。
