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Gamma interferon expression and major histocompatibility complex induction during measles and vesicular stomatitis virus infections of the brain.麻疹病毒和水疱性口炎病毒感染脑部期间γ干扰素的表达及主要组织相容性复合体的诱导
J Neuroimmunol. 1991 Jan;31(1):19-26. doi: 10.1016/0165-5728(91)90082-i.
2
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Central neuropathogenesis of vesicular stomatitis virus infection of immunodeficient mice.免疫缺陷小鼠感染水疱性口炎病毒的中枢神经发病机制
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麻疹病毒和水疱性口炎病毒感染脑部期间γ干扰素的表达及主要组织相容性复合体的诱导

Gamma interferon expression and major histocompatibility complex induction during measles and vesicular stomatitis virus infections of the brain.

作者信息

Gogate N, Bakhiet M, Kristensson K, Norrby E, Olsson T

机构信息

Department of Cellular and Neuropathology, Huddinge Hospital, Sweden.

出版信息

J Neuroimmunol. 1991 Jan;31(1):19-26. doi: 10.1016/0165-5728(91)90082-i.

DOI:10.1016/0165-5728(91)90082-i
PMID:1845767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7119734/
Abstract

Lymphocytic interferon gamma (IFN-gamma) production and major histocompatibility complex (MHC) antigen induction were studied in experimental measles and vesicular stomatitis virus infections in the brain. Fifteen-day-old Sprague-Dawley rats injected intracerebrally with the HNT strain of measles virus showed already within 1 day after infection an increased number of cells producing IFN-gamma in the spleen, cervical lymph nodes and leptomeninges. These rats recovered after a transient neuronal infection in the brain. Rats infected intracerebrally with vesicular stomatitis virus, on the other hand, all succumbed after 2 days and showed no IFN-gamma production in lymphoid cells. Immunohistochemically MHC class I antigen appeared in infected and uninfected cells in the brain during replication of both viruses. A role for the recently discovered nerve fibres with IFN-gamma-like immunoreactivity, which are normally present in the brain, in the MHC antigen induction is discussed.

摘要

在脑内实验性麻疹和水疱性口炎病毒感染中，研究了淋巴细胞干扰素γ（IFN-γ）的产生及主要组织相容性复合体（MHC）抗原的诱导情况。15日龄的斯普拉格-道利大鼠脑内注射麻疹病毒HNT株后，感染后1天内脾脏、颈淋巴结和软脑膜中产生IFN-γ的细胞数量就已增加。这些大鼠在脑内短暂的神经元感染后恢复。另一方面，脑内感染水疱性口炎病毒的大鼠在2天后全部死亡，且淋巴细胞中未检测到IFN-γ的产生。免疫组织化学研究显示，在两种病毒复制期间，脑内感染和未感染的细胞中均出现了MHC I类抗原。本文讨论了脑内正常存在的具有IFN-γ样免疫反应性的新发现神经纤维在MHC抗原诱导中的作用。