Maehlen J, Olsson T, Löve A, Klareskog L, Norrby E, Kristensson K
Department of Pathology, Huddinge Hospital, Sweden.
J Neuroimmunol. 1989 Feb;21(2-3):149-55. doi: 10.1016/0165-5728(89)90170-7.
Fourteen-day-old Lewis rats were injected intracerebrally with the hamster neurotropic (HNT) strain of measles virus. At the same time, CD8+ T cytotoxic cells were eliminated by a single injection of a mouse monoclonal antibody (Ox8) directed against this lymphocyte phenotype. The lymphocyte depletion, which endured for more than 7 weeks, markedly reduced the elimination of measles virus antigen from the brain, but did not affect the induction of major histocompatibility complex (MHC) molecules in the early phase of infection. These results demonstrate a role for MHC class I-restricted CD8+ T cells in controlling persistence of measles virus infection in neurons.
将14日龄的Lewis大鼠脑内注射仓鼠嗜神经（HNT）株麻疹病毒。同时，通过单次注射针对这种淋巴细胞表型的小鼠单克隆抗体（Ox8）来清除CD8 + T细胞毒性细胞。持续超过7周的淋巴细胞耗竭显著减少了脑内麻疹病毒抗原的清除，但不影响感染早期主要组织相容性复合体（MHC）分子的诱导。这些结果证明了MHC I类限制性CD8 + T细胞在控制神经元中麻疹病毒感染持续性方面的作用。
