Muthutantri Anushini I, Huang Jie, Edirisinghe Mohan J, Bretcanu Oana, Boccaccini Aldo R
Department of Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.
Biomed Mater. 2008 Jun;3(2):025009. doi: 10.1088/1748-6041/3/2/025009. Epub 2008 Apr 29.
A novel fabrication technique, a combination of slurry dipping and electrospraying, was used to produce hydroxyapatite foams as potential matrices for bone tissue engineering applications. In this study, scaffolds that were slurry dipped and electrosprayed for different time intervals were compared with foams prepared by the individual methods of dipping and electrospraying. Significant differences in the distribution of cracks on the struts, the strut thickness and porosity were observed on the sintered foams prepared under the varied conditions. All the sintered structures had average porosities in the range 84-94% and desirable pore interconnections, while the combined method produced foams of uniform pore distribution, thicker struts and improved mechanical properties. Further improvement of the mechanical properties has also been achieved by altering the sintering conditions.
一种新型制造技术，即浆料浸渍与电喷雾相结合的技术，被用于制备羟基磷灰石泡沫，作为骨组织工程应用的潜在基质。在本研究中，将在不同时间间隔进行浆料浸渍和电喷雾处理的支架与通过单独的浸渍和电喷雾方法制备的泡沫进行了比较。在不同条件下制备的烧结泡沫上，观察到支柱上裂纹分布、支柱厚度和孔隙率存在显著差异。所有烧结结构的平均孔隙率在84 - 94%范围内，且具有理想的孔隙互连，而组合方法制备的泡沫具有均匀的孔隙分布、更厚的支柱和改善的机械性能。通过改变烧结条件，机械性能也得到了进一步改善。
