CNRS, Université de Bordeaux, ICMCB, 87 avenue du Dr. A. Schweitzer, Pessac F-33608, France.
Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Pulka 3, Riga LV-1007, Latvia.
J Funct Biomater. 2015 Dec 21;6(4):1099-140. doi: 10.3390/jfb6041099.
In the last five decades, there have been vast advances in the field of biomaterials, including ceramics, glasses, glass-ceramics and metal alloys. Dense and porous ceramics have been widely used for various biomedical applications. Current applications of bioceramics include bone grafts, spinal fusion, bone repairs, bone fillers, maxillofacial reconstruction, etc. Amongst the various calcium phosphate compositions, hydroxyapatite, which has a composition similar to human bone, has attracted wide interest. Much emphasis is given to tissue engineering, both in porous and dense ceramic forms. The current review focusses on the various applications of dense hydroxyapatite and other dense biomaterials on the aspects of transparency and the mechanical and electrical behavior. Prospective future applications, established along the aforesaid applications of hydroxyapatite, appear to be promising regarding bone bonding, advanced medical treatment methods, improvement of the mechanical strength of artificial bone grafts and better in vitro/in vivo methodologies to afford more particular outcomes.
在过去的五十年中,生物材料领域取得了巨大的进展,包括陶瓷、玻璃、玻璃陶瓷和金属合金。致密陶瓷和多孔陶瓷已广泛应用于各种生物医学应用。生物陶瓷的当前应用包括骨移植物、脊柱融合、骨修复、骨填充物、颌面重建等。在各种磷酸钙成分中,具有与人骨相似组成的羟基磷灰石引起了广泛的关注。多孔和致密陶瓷形式的组织工程都受到了高度重视。本综述重点介绍了致密羟基磷灰石和其他致密生物材料在透明度以及机械和电气性能方面的各种应用。根据羟基磷灰石的上述应用,预期未来的应用在骨结合、先进的医疗方法、提高人工骨移植物的机械强度以及更好的体外/体内方法方面似乎很有前途,以获得更特殊的结果。