Ito Atsuo, Senda Koji, Sogo Yu, Oyane Ayako, Yamazaki Atsushi, Legeros Racquel Z
National Institute of Advanced Industrial Science and Technology, Institute for Human Science and Biomedical Engineering, Central 6, 1-1-1, Higashi, Tsukuba, Ibaraki 305-8566, Japan.
Biomed Mater. 2006 Sep;1(3):134-9. doi: 10.1088/1748-6041/1/3/007. Epub 2006 Jun 21.
The dissolution rates of ceramic tricalcium phosphate (TCP) and zinc-containing tricalcium phosphate (ZnTCP) ceramics at pH 5.5 decrease with increasing zinc content. The relative dissolution rates of ceramic ZnTCP with zinc contents of 0.5 and 1.0 mol% are more than three times higher than the relative resorbed volumes of these ZnTCP ceramics which were reported previously. The dissolution rates are likely controlled by only one mechanism, that is polynucleation, in the zinc content range from 0 to 1.0 mol%. Since the surface area of ceramic TCP or ZnTCP is much lower than that of powdered TCP or ZnTCP, the initial dissolution flux of ceramic TCP or ZnTCP remains unchanged for a longer period than that of powdered TCP. As a result, no change in dissolution kinetics is expected during one cycle of osteoclastic resorption. Since neither the dissolution rate nor the change in dissolution kinetics accounts for the previously reported drastic reduction in osteoclastic resorption associated with ZnTCP, it is concluded that the drastic reduction in resorption arises from the suppressive effects of ZnTCP on osteoclast formation or osteoclastic activity.
陶瓷磷酸三钙（TCP）和含锌磷酸三钙（ZnTCP）陶瓷在pH 5.5时的溶解速率随锌含量的增加而降低。锌含量为0.5和1.0 mol%的陶瓷ZnTCP的相对溶解速率比先前报道的这些ZnTCP陶瓷的相对再吸收体积高三倍多。在锌含量为0至1.0 mol%的范围内，溶解速率可能仅受一种机制控制，即多核化。由于陶瓷TCP或ZnTCP的表面积远低于粉末状TCP或ZnTCP的表面积，陶瓷TCP或ZnTCP的初始溶解通量比粉末状TCP的初始溶解通量在更长时间内保持不变。因此，在破骨细胞再吸收的一个周期内，预计溶解动力学不会发生变化。由于溶解速率和溶解动力学的变化均不能解释先前报道的与ZnTCP相关的破骨细胞再吸收的急剧减少，因此得出结论，再吸收的急剧减少源于ZnTCP对破骨细胞形成或破骨细胞活性的抑制作用。
