Agostoni Carlo, Marangoni Franca, Stival Giorgio, Gatelli Italo, Pinto Francesca, Risé Patrizia, Giovannini Marcello, Galli Claudio, Riva Enrica
Department of Pediatrics, University of Milan, Milan, Italy.
Pediatr Res. 2008 Sep;64(3):298-302. doi: 10.1203/PDR.0b013e31817d9c23.
To investigate the associations between whole blood fatty acid (FA) profile and restricted intrauterine growth, any small for gestational age (SGA) infant born in our maternity ward through 1 y was matched with two appropriate for gestational age (AGA), of the same GA +/- 0.5 wk, infants, further subdivided into term and preterm. Whole blood was collected at d 4 on a strip and FA % composition assessed by means of gas chromatography. The whole sample consisted of 28 SGA versus 56 AGA born at term and 20 SGA versus 40 AGA born preterm at around 35 wks. Parent FA of the n-6 and n-3 FA families were higher in preterm groups, whereas docosahexaenoic acid was higher in term AGA (median % values, 3.9 versus 3.7 in term SGA, 2.8 in preterm AGA, and 2.5 in preterm SGA, p < 0.001). Term AGA had markedly higher values for the docosahexaenoic acid/alpha-linolenic acid ratio (median value: 91, versus 18 in term SGA, 12 in preterm AGA, and 10 in preterm SGA, p < 0.001). Term SGA had significantly lower levels of total monounsaturated FA and higher levels of eicosapentaenoic acid. Therefore, the 4-d whole blood FA pattern is associated with both GA and birth weight.
为了研究全血脂肪酸（FA）谱与宫内生长受限之间的关联，对我院产科病房1年内出生的任何小于胎龄（SGA）婴儿，与两名胎龄相同（±0.5周）的适于胎龄（AGA）婴儿进行匹配，并进一步分为足月儿和早产儿。在出生第4天用试纸条采集全血，通过气相色谱法评估FA的百分比组成。整个样本包括28例足月出生的SGA婴儿与56例足月出生的AGA婴儿，以及20例孕35周左右早产的SGA婴儿与40例早产的AGA婴儿。n-6和n-3 FA家族的母体FA在早产组中较高，而二十二碳六烯酸在足月AGA组中较高（中位数百分比值，足月SGA组为3.9，足月AGA组为3.7，早产AGA组为2.8，早产SGA组为2.5，p<0.001）。足月AGA组的二十二碳六烯酸/α-亚麻酸比值明显更高（中位数：91，而足月SGA组为18，早产AGA组为12，早产SGA组为10，p<0.001）。足月SGA组的总单不饱和FA水平显著较低，而二十碳五烯酸水平较高。因此，出生第4天的全血FA模式与胎龄和出生体重均有关联。
