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[慢性伤口的未来治疗选择]

[Future treatment options for chronic wounds].

作者信息

Steinsträsser L, Hasler R, Hirsch T, Daigeler A, Langer S, Steinau H U

机构信息

Klinik für Plastische Chirurgie und Schwerbrandverletzte, BG-Universitätsklinikum Bergmannsheil, Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Deutschland.

出版信息

Chirurg. 2008 Jun;79(6):555-9. doi: 10.1007/s00104-008-1504-z.

DOI:10.1007/s00104-008-1504-z
PMID:18458798
Abstract

The skin plays an important role in the human immune system, working as a barrier to pathologic influences. A chronic wound breaks that barrier and eliminates that function. Affected patients can suffer from significant reductions in quality of life and become socially isolated. The inability to work may have serious economic consequences for the individual and the community. Treating these wounds with novel, evidence-based techniques can accelerate wound healing while reducing the length of in- and outpatient treatment and thereby the overall costs. This article discusses current and future treatment options in wound conditioning, therapy, and regeneration.

摘要

皮肤在人体免疫系统中发挥着重要作用,作为抵御病理影响的屏障。慢性伤口破坏了这一屏障并消除了该功能。受影响的患者生活质量可能会大幅下降,并在社交上变得孤立。无法工作可能会给个人和社区带来严重的经济后果。采用新颖的、基于证据的技术治疗这些伤口可以加速伤口愈合,同时缩短住院和门诊治疗时间,从而降低总体成本。本文讨论了伤口预处理、治疗和再生方面当前和未来的治疗选择。

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本文引用的文献

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Host defense peptides and the new line of defence against multiresistant infections.宿主防御肽与抗多重耐药感染的新防线
Protein Pept Lett. 2008;15(3):238-43. doi: 10.2174/092986608783744252.
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Therapeutic ultrasound for venous leg ulcers.用于治疗腿部静脉溃疡的超声疗法
Cochrane Database Syst Rev. 2008 Jan 23(1):CD001180. doi: 10.1002/14651858.CD001180.pub2.
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Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings.慢性伤口的治疗:非愈合伤口护理及伤口护理敷料的实用方法。
J Am Acad Dermatol. 2008 Feb;58(2):185-206. doi: 10.1016/j.jaad.2007.08.048.
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Clinical and microbiological efficacy of MDT in the treatment of diabetic foot ulcers.多药联合疗法治疗糖尿病足溃疡的临床及微生物学疗效
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5
Silver-impregnated vacuum-assisted closure in the treatment of recalcitrant venous stasis ulcers.银浸渍负压封闭引流术治疗顽固性静脉淤滞性溃疡
Ann Plast Surg. 2007 Jul;59(1):58-62. doi: 10.1097/01.sap.0000263420.70303.cc.
6
Preoperative bathing or showering with skin antiseptics to prevent surgical site infection.术前使用皮肤消毒剂沐浴或淋浴以预防手术部位感染。
Cochrane Database Syst Rev. 2007 Apr 18(2):CD004985. doi: 10.1002/14651858.CD004985.pub3.
7
Larval therapy: a novel treatment in eliminating methicillin-resistant Staphylococcus aureus from diabetic foot ulcers.幼虫疗法:一种从糖尿病足溃疡中清除耐甲氧西林金黄色葡萄球菌的新疗法。
Diabetes Care. 2007 Feb;30(2):370-1. doi: 10.2337/dc06-2348.
8
Guidelines for the treatment of diabetic ulcers.糖尿病溃疡治疗指南。
Wound Repair Regen. 2006 Nov-Dec;14(6):680-92. doi: 10.1111/j.1524-475X.2006.00176.x.
9
Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers.重组人血小板衍生生长因子治疗下肢溃疡的临床评估
Plast Reconstr Surg. 2006 Jun;117(7 Suppl):143S-149S; discussion 150S-151S. doi: 10.1097/01.prs.0000222526.21512.4c.
10
Chronic wound pathogenesis and current treatment strategies: a unifying hypothesis.慢性伤口发病机制与当前治疗策略:一个统一的假说。
Plast Reconstr Surg. 2006 Jun;117(7 Suppl):35S-41S. doi: 10.1097/01.prs.0000225431.63010.1b.