Helpap Burkhard, Egevad Lars
Department of Pathology, General Hospital HBH Kliniken Singen, Academic Hospital of the University of Freiburg, Singen, Germany.
Anal Quant Cytol Histol. 2008 Feb;30(1):1-7.
To study the correlation between modified Gleason score (GS) and pT stage of radical prostatectomy (RP) specimens.
Six hundred forty-nine consecutive RP specimens were graded according to the conventional and the modified Gleason grading systems.
A total of 29% of the tumors were upgraded. Both variants of GS correlated with pathologic stage. Stage pT2 tumors were assigned a GS of 3-6 less often with modified grading than with conventional grading (29% and 84%, respectively). The only significant difference of stage distribution between conventional and modified GS was for GS 7, where pT2 was the most common stage with modified grading (54%) and pT3 was most common with conventional grading (67%). Of GS 3 + 4 = 7a tumors, 95% were stage pT2, while 79% of GS 4 + 3 = 7b tumors were stage pT3-4.
The stage distribution of modified GSs of RP specimens differs from that of conventional GSs, but a good correlation exists between grade and pT stage. Notably, GS 4 + 3 = 7b was more often associated with high stage than was GS 3 + 4 = 7a.
研究改良Gleason评分（GS）与前列腺癌根治术（RP）标本的pT分期之间的相关性。
根据传统和改良Gleason分级系统对649例连续的RP标本进行分级。
共有29%的肿瘤分级上调。两种GS变体均与病理分期相关。pT2期肿瘤采用改良分级时被赋予3 - 6分的GS的频率低于传统分级（分别为29%和84%）。传统和改良GS之间分期分布的唯一显著差异在于GS 7，改良分级时pT2是最常见分期（54%），传统分级时pT3是最常见分期（67%）。在GS 3 + 4 = 7a的肿瘤中，95%为pT2期，而GS 4 + 3 = 7b的肿瘤中79%为pT3 - 4期。
RP标本改良GS的分期分布与传统GS不同，但分级与pT分期之间存在良好的相关性。值得注意的是，与GS 3 + 4 = 7a相比，GS 4 + 3 = 7b更常与高分期相关。
