van Dommelen Paula, de Gunst Mathisca, van der Vaart Aad, van Buuren Stef, Boomsma Dorret
Department of Mathematics, Free University, Amsterdam, The Netherlands.
Acta Paediatr. 2008 Aug;97(8):1099-104. doi: 10.1111/j.1651-2227.2008.00853.x. Epub 2008 May 6.
To determine the size of the growth deficit in Dutch monozygotic and dizygotic twins aged 0-2.5 years as compared to singletons and to construct reference growth charts for twins.
Growth of twins was studied using longitudinal data on over 4000 twins aged 0-2.5 years of the Netherlands Twin Register. The LMS method was used to obtain growth references for length/height, weight, and body mass index (BMI) for twins.
During the first 2.5 years of age, differences in length/height and weight between twins and singletons decrease but do not disappear. BMI of twins deviates less than that of singletons. Approximately half of the growth retardation from birth until 1.5 years of age was attributable to gestational age. Between 1.5 years and 2.5 years of age, this difference was reduced to one-third. Thus, a substantial part of the growth difference could not be explained by gestational age.
During the first 2.5 years of life, there is a difference in growth between twins and singletons. Twins catch up in their body size, i.e. they grow faster after birth, but do not yet achieve the same height and weight till they reach 2.5 years of age. We recommend the use of the growth references for twins.
确定0至2.5岁荷兰单卵双胞胎和双卵双胞胎与单胎婴儿相比生长发育迟缓的程度,并构建双胞胎的生长参考图表。
利用荷兰双胞胎登记处4000多名0至2.5岁双胞胎的纵向数据研究双胞胎的生长情况。采用LMS方法获取双胞胎身长/身高、体重和体重指数(BMI)的生长参考值。
在2.5岁之前,双胞胎与单胎婴儿在身长/身高和体重上的差异逐渐减小,但并未消失。双胞胎的BMI偏差小于单胎婴儿。从出生到1.5岁,约一半的生长迟缓归因于胎龄。在1.5岁至2.5岁之间,这种差异降至三分之一。因此,很大一部分生长差异无法用胎龄来解释。
在生命的前2.5年,双胞胎与单胎婴儿的生长存在差异。双胞胎在体型上会追赶上来,即出生后生长更快,但在2.5岁之前身高和体重仍未达到相同水平。我们建议使用双胞胎的生长参考值。