Löwik M R, Wedel M, Kok F J, Odink J, Westenbrink S, Meulmeester J F
Department of Human Nutrition, TNO-CIVO, Toxicology and Nutrition Institute, Zeist, The Netherlands.
J Gerontol. 1991 Jan;46(1):M23-8. doi: 10.1093/geronj/46.1.m23.
Associations of serum cholesterol with relevant dietary intake variables (assessed with the dietary history method) and body mass index were investigated in elderly men (n = 199) and women (n = 180) 65-79 years old. All subjects were apparently healthy, nondiabetic, and not on a dietary regimen. The associations were studied separately for men and women using linear regression analysis and all possible subsets regression analysis. Among men, body mass index (kg/m2) and intake of monounsaturated fat and of alcohol were positively and consistently associated with serum total cholesterol. Among women, intake of alcohol and of saturated fat were positively associated, and intake of polysaccharides was inversely associated with serum total cholesterol. The intake of monounsaturated fatty acids was highly (r greater than .60) positively correlated with the intake of total fat and saturated fatty acids, and inversely with carbohydrates. HDL-cholesterol was positively associated with alcohol intake (significant for men only), and inversely with body mass index (women). The results indicate that the effect of dietary factors on serum cholesterol levels is probably not age-limited. Elderly people may potentially benefit from weight reduction or control, moderate alcohol consumption, and avoidance of too much dietary fat. These suggestions are in fair accordance with general population-based guidelines for a healthy diet. However, as our study was cross-sectional, causation as well as the public health impact remains to be proven.
在199名老年男性(65至79岁)和180名老年女性(65至79岁)中,研究了血清胆固醇与相关饮食摄入变量(采用饮食史方法评估)以及体重指数之间的关联。所有受试者均表面健康、无糖尿病且未遵循饮食疗法。使用线性回归分析和所有可能的子集回归分析分别对男性和女性的这些关联进行了研究。在男性中,体重指数(kg/m²)、单不饱和脂肪摄入量和酒精摄入量与血清总胆固醇呈持续正相关。在女性中,酒精摄入量和饱和脂肪摄入量与血清总胆固醇呈正相关,而多糖摄入量与血清总胆固醇呈负相关。单不饱和脂肪酸的摄入量与总脂肪和饱和脂肪酸的摄入量高度正相关(r大于0.60),与碳水化合物摄入量呈负相关。高密度脂蛋白胆固醇与酒精摄入量呈正相关(仅对男性有显著意义),与体重指数呈负相关(女性)。结果表明,饮食因素对血清胆固醇水平的影响可能不受年龄限制。老年人可能会从减轻体重或控制体重、适度饮酒以及避免摄入过多膳食脂肪中获益。这些建议与基于一般人群的健康饮食指南相当一致。然而,由于我们的研究是横断面研究,因果关系以及对公共卫生的影响仍有待证实。